Evidence map›Paper›PMID 40898824›Full record

ArticleRenal failure2025

Investigating the genetic effects of metformin-related targets on IgA nephropathy using Mendelian randomization.

Yan Zhang, Jinyan Lin, Peizhuang Zheng, Xingtao Lin, Daowen Zheng

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Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Yan ZhangDepartment of Ophthalmology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Jinyan LinDepartment of Health Management, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Peizhuang ZhengDepartment of Medical Imaging, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xingtao LinDepartment of Pathology, Guangdong Provincial People's Hospital, Guangzhou, China.
Daowen ZhengDepartment of Gerontology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of metformin and its downstream targets in IgA nephropathy (IgAN) remains unclear. In this study, we used Mendelian randomization to explore potential causal links between genetic proxies of metformin targets, plasma proteins, and the risk of IgAN. Data on plasma protein, metformin target genes, and IgAN data were obtained from the IEU OpenGWAS Project. Single-nucleotide polymorphisms (SNPs) associated with metformin target genes and plasma proteins were selected as instrumental variables. We applied a two-sample and two-step Mendelian randomization approach to examine the causal relationships among these variables. Inverse variance weighted analysis revealed that electron transport flavoprotein dehydrogenase (ETFDH) inhibitors were associated with a reduced risk of IgAN (odds ratio [OR] = 0.948, 95% confidence interval [CI]: 0.923-0.973,

Indexed as

Glomerulonephritis, IGAHypoglycemic AgentsMetforminBlood ProteinsHumansMaleMendelian Randomization AnalysisPolymorphism, Single NucleotideRisk FactorsBlood ProteinsHypoglycemic AgentsMetforminETFDHImmunoglobulin a nephropathyMendelian randomizationmetformin

Identifiers

PMID40898824
PMCPMC12409868

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.