ArticleJournal of applied toxicology : JAT2026
A Multimodal Approach to Identify Metallothionein Metal Inducers in Nile Tilapia: Insights From Molecular Docking and Hepatocyte Exposure.
Article in Journal of applied toxicology : JAT, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A Multimodal Approach to Identify Metallothionein Metal Inducers in Nile Tilapia: Insights From Molecular Docking and Hepatocyte Exposure.Journal of applied toxicology : JAT · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
Many human activities contribute to the pollution of aquatic ecosystems, primarily through agricultural, industrial, mining, and domestic discharges into water bodies. Fish, being highly sensitive to environmental changes, serve as valuable models for monitoring the health of these ecosystems. Metallothionein (Mt), a biomarker for metal contamination, shows variable expression depending on the metal involved. Transcription of the mt gene is regulated by intracellular metal concentrations and mediated by interactions between metal-responsive transcription factors (Mtf) and metal response elements (MRE) in the mt promoter. Zinc plays a key role by binding to Mtf, activating it, and enabling interaction with MRE sequences to initiate transcription. In this context, this study aimed to identify the most potent inducers of mt expression in Oreochromis niloticus. Initially, zinc-binding proteins from O. niloticus were modeled to assess differential binding scores of various metals using molecular docking, which suggested the potency ranking Cd
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