SynthesisBrain and behavior2025
Traditional Chinese Medicinal Herbs for Treating Post-Ischemic Stroke Cognitive Impairment Insights From Frequency and Association Analysis.
Synthesis in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Traditional Chinese Medicinal Herbs for Treating Post-Ischemic Stroke Cognitive Impairment Insights From Frequency and Association Analysis.Brain and behavior · 2025Pooled it
- From "Monarch, Minister, Assistant, and Envoy" to "Microbial Dialogue": A Review of Novel Mechanisms by Which Chinese Herb Pairs Improve Metabolic Diseases Through Gut Microbiota Metabolic Regulation.Gastroenterology research and practice · 2026Review
- Integrative Traditional Chinese Medicine Strategies for Refractory Mycoplasma Pneumonia in Children: Clinical Challenges, Mechanisms, and Evidence-Based Insights.Infection and drug resistance · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThis study analyzes medicinal herbs in Traditional Chinese Medicine (TCM) formulations for post-ischemic stroke cognitive impairment, identifying key herbs, their interactions, and potential therapeutic mechanisms through systematic review, frequency analysis, and association rule mining.
methodsSystematic searches were performed across major databases (CBM, CNKI, VIP, Wanfang Data) to find studies on TCM for post-ischemic stroke cognitive impairment. Inclusion criteria focused on studies reporting TCM formulas and their cognitive effects. Data extraction standardized herb names, and frequency analysis identified high-frequency herbs (>10%). Association rule mining was done using Python with a minimum support of 10%, a minimum confidence of 50%, and a maximum antecedent size of 5 to uncover key herb associations for therapeutic insights.
resultsA systematic review identified 56 studies on TCM formulas for post-ischemic stroke cognitive impairment, extracting 114 herbs. Frequency analysis found 27 herbs used in over 10% of formulas, with Ligusticum chuanxiong, Acorus tatarinowii, and Salvia miltiorrhiza being most common. Association rule mining revealed key combinations, suggesting potential synergistic effects in TCM treatments.
conclusionThis study highlights key traditional Chinese herbs and herb combinations commonly used in clinical practice for cognitive impairment after ischemic stroke. The findings suggest that herb pairs such as Ligusticum chuanxiong-Salvia miltiorrhiza and Acorus tatarinowii-Polygala tenuifolia may exert synergistic effects consistent with both TCM theory and modern pharmacology. These results provide direction for future targeted studies and support the rational formulation of TCM-based interventions in stroke rehabilitation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.