Trial reportInternational journal of paediatric dentistry2026
Plaque and Salivary Fluoride Levels in Preschoolers Following Applications of Silver Diamine Fluoride, Sodium Fluoride Varnish, and Their Combination: A Randomized Clinical Trial.
Trial report in International journal of paediatric dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
backgroundThe amount of fluoride maintained in the oral cavity aids in the remineralization process. HYPOTHESIS/
aimTo evaluate and compare plaque and salivary fluoride levels following applications of silver diamine fluoride (SDF), sodium fluoride varnish (NaFV), or both.
designSixty preschoolers randomly received 38% SDF, 5% NaFV, or both (SDF + NaFV). Plaque and saliva were collected at baseline; 5, 30, and 60 min; and 24 and 48 h post-application. Fluoride levels in plaque and saliva were evaluated and statistically compared (p < 0.05).
resultsSalivary fluoride levels peaked 5 min post-application in all groups and recovered to baseline within 1 to 24 h. Plaque fluoride levels peaked between 5 and 60 min, then returned to baseline within 1 to 24 h. The SDF group had significantly lower plaque and salivary fluoride levels than the other groups. There were no differences in plaque or salivary fluoride levels between NaFV and SDF + NaFV groups; however, the SDF + NaFV group had the longest salivary fluoride retention.
conclusionsThe application of SDF in combination with NaFV (highest fluoride exposure) resulted in higher fluoride levels in plaque and saliva of preschoolers. Since these levels returned to baseline in less than 24 h, further studies are required to establish the implications for caries arrest and prevention.
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