SynthesisMedicine2025
Human genetic diversity across South Asian populations: A systematic review and meta-analysis.
Synthesis in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Post-COVID syndrome in Pakistan, India, and Bangladesh: a systematic narrative review of epidemiology, clinical manifestations, and healthcare system responses.Frontiers in public health · 2026Pooled it
- Roles of the E3 Ubiquitin Ligase TRIM47 in Inflammation, Organ Injury, and Cancer.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSouth Asia comprises genetically diverse populations because its populations have experienced multiple migrations combined with endogamy and isolation throughout history. Research on large-scale genetic variation patterns in this region remains scarce. This study aims to perform both a systematic review and meta-analysis of research about genetic diversity in South Asian populations.
methodsThe PubMed database yielded 3798 studies within the time frame from 2010 to 2025. The analysis included 57 studies that fulfilled the required criteria after initial screening. The random-effects model processed pooled F_ST values together with heterozygosity estimates and allele frequency variation across ethnic subgroups.
resultsThe genetic differentiation (F_ST) measurements between significant South Asian groups extended from 0.02 to 0.15. The homozygosity levels were significantly higher in tribal populations (mean runs of homozygosity = 0.38) than in caste groups. The combined F_ST value reached 0.072 with a 95% confidence interval ranging from 0.061 to 0.084. The highest heterozygosity values existed among North Indian speakers of the Indo-European language, while isolated tribal populations showed the lowest heterozygosity levels.
conclusionThe genetic structure of South Asia extends deep into its population because of geographical barriers as well as linguistic and social organization systems. The diverse genetic makeup of populations affects both disease risk profiles and precision medical approaches for individual groups.
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Registered trials
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