ArticleAIDS research and therapy2025
Hypoalbuminemia in HIV-infected patients: its determinants and correlation with CD4 count in Northern Uganda.
Article in AIDS research and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Voriconazole therapeutic drug monitoring and safety in HIV-infected patients with invasive fungal disease.Frontiers in pharmacology · 2026Article
- Age-Related Variations in Clinical and Biochemical Profiles of People Living With HIV.AIDS research and treatment · 2026Article
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9 authors.
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Abstract
introductionHypoalbuminemia is linked to an earlier onset of acquired immune deficiency syndrome and increased mortality in patients living with HIV infection. Serum albumin is therefore an independent factor for the prediction of disease progression and mortality in People Living With HIV.
methodsThis was a cross-sectional study conducted at Lira Regional Referral Hospital in northern Uganda that targeted HIV-positive outpatients attending the ART clinic with a sample size of 373 patients. Data were collected through structured interviews and laboratory tests in which the serum albumin concentration, viral load, and CD4 count were measured.
resultsThe prevalence of hypoalbuminemia was 19.6% (73/373). A moderate positive correlation was observed between the serum albumin concentration and the CD4 count (rs = 0.43, p < 0.001). Patients with no formal education [AOR = 2.03, 95%CI = 1.69-2.07, P = 0.03] were 2.03 times more likely to have hypoalbuminemia than those who had a tertiary/university education level. The odds of having hypoalbuminemia [AOR = 2.17, CI = 1.80-3.06, P = 0.02] were 2.17 higher among HIV-infected patients who were naïve ART than among those who were on ART. Additionally, the odds of having hypoalbuminemia [AOR = 2.91, CI = 2.13-3.66, P = 0.01] were 2.91 higher among HIV-infected patients who were in stage four than among those who were in stage 1.
conclusionHypoalbuminemia prevalence was high in PLWHIV, and a moderate positive correlation was found between the serum albumin level and the CD4 cell count. Lower education level, not being ART, and advanced HIV disease were independently associated with hypoalbuminemia.
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