ArticleBMC women's health2025
Global, regional and national uterine fibroid burdens from 1990 to 2021 and projections until 2050: results from the GBD study.
Article in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Adenomyosis and Uterine Fibroids: Two Distinct Yet Overlapping Clinical Entities.Diagnostics (Basel, Switzerland) · 2026Review
- Exploratory Preoperative Risk Stratification of Uterine Mesenchymal Tumors in Postmenopausal Women with Complementary Transcriptomic Analysis.Diagnostics (Basel, Switzerland) · 2026Article
- Uterine cellular leiomyoma with a novel HMGA2::PLCZ1 fusion and aberrant cyclin D1 expression: expanding the molecular spectrum and highlighting a diagnostic pitfall.Virchows Archiv : an international journal of pathology · 2026Article
- Burden and Risk Factor Patterns of Reproductive System Tumors and Non-Tumor Diseases Among Asian Women, 1990-2021: Evidence from the GBD Study.International journal of women's health · 2026Article
- Cost analysis of hospital-based symptomatic uterine fibroids in the kingdom of Eswatini: A prevalence-based cost-of-illness study.PloS one · 2026Article
- Uterine Leiomyomas with Intravenous Leiomyomatosis: A Report of Two Cases.International journal of women's health · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundUterine fibroids(UF), while histologically benign, constitute a pervasive yet inequitable epidemiological phenomenon characterized by disproportionately distributed morbidity burdens that correlate asymmetrically with regional development levels, compounded by intersecting socioeconomic determinants and genetic susceptibilities. We aimed to assess the global and regional burden of age-standardized UF in women from 1990 to 2021.
methodsAge-standardized incidence, prevalence, and years lived with disability (YLDs) rates attributable to UF were obtained from the Global Burden of Disease (GBD) Study 2021. Temporal trends were evaluated using the average annual percentage change (AAPC), and future projections were conducted using the autoregressive integrated moving average (ARIMA) model.
resultsFrom 1990 to 2021, the global Age-standardized prevalence rate (ASPR) increased (AAPC = 0.05; 95% CI: 0.03 to 0.08), with the high increases occurring in Brazil, India, and Georgia. The Age-standardized incidence rate (ASIR) also increased globally (AAPC = 0.23; 95% CI: 0.19 to 0.27), although it declined in Poland. Age-standardized years lived with disability (YLDs) followed a similar global upward trend (AAPC = 0.09; 95% CI: 0.07 to 0.12) but decreased in some regions, including China, and Australia. The high-middle-SDI regions exhibited declining trends, whereas the low-middle-SDI regions exhibited increasing trends. Our projections suggested stabilization of these indicators by 2050.
conclusionsUF remain the most common benign gynecological tumors and pose a substantial health care burden. Socioeconomic factors, diagnostic advancements, and lifestyle changes influence the long-term trends associated with their prevalence, incidence, and other related parameters. Increased epidemiological surveillance and more public health interventions are needed.
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