Evidence map›Paper›PMID 40898227›Full record

ArticleBMC oral health2025

Immunological balance skewing Th1,Th17 towards Th2,Treg in OSCC of hamster induced by 7,12- dimethylbenz[a]anthracene.

Qi Shao, Hongyuan Li, Yuanye Tian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Research Progress of Peripheral Immune Tolerance in Oral Diseases].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Qi ShaoDepartment of Craniomaxillofacial Plastic and Cosmetic Center, Hospital of Stomatology, Jilin University, No.1500 Qinghua Road, Changchun, Jilin, 130021, China.
Hongyuan LiDepartment of Oral and Maxillofacial Surgery, Xiangya Stomalogical Hospital & School of Stomatology, Central South University, Changsha, Hunan, 410078, China.
Yuanye TianDepartment of Craniomaxillofacial Plastic and Cosmetic Center, Hospital of Stomatology, Jilin University, No.1500 Qinghua Road, Changchun, Jilin, 130021, China. tyy@jlu.edu.cn.

Funding

Jilin Provincial Department of Education Project JJKH20241343KJJilin Provincial Department of Finance Project jcsz2023481-30
6 · The paper itself

Abstract

backgroundIt has been reported that CD4 + helper T cells, such as Th1, Th2, Th17 and Treg, play crucial roles in the immunological balance especially when the immune system is invaded by the tumor. Oral squamous cell carcinoma undergoes a process from normal epithelium to dysplasia. However, the dynamic equilibrium of Th1/Th2 and Th17/Treg remained unclear during the process of epithelial malignant transformation. The present study was performed to describe the changes of Th1, Th2, Th17, Treg, Th1/Th2 and Th17/Treg in golden hamsters induced Oral Potentially malignant Disorders (OPMDs) and oral squamous cell carcinoma.

methodsUsing the carcinogenic agent 7,12-dimethylbenz [a]anthracene to smear the Syrian golden hamster cheek pouch mucosa every 3 days, OPMDs and oral squamous cell carcinoma models had been induced. Samples were obtained surgically from the hamster, grind into single cell suspension, and tested by flow cytometry.

resultWith the increasing of Th2 and Treg has been the decreasing of Th1 and Th17 from normal epithelium to OPMDs and oral squamous cell carcinoma. Th1/Th2 ratio and Th17/Treg ratio were changing in the different lesion.

conclusionOur findings suggested that the shift of Th1/Th2 balance to Th2 might involve in the occurrence and development of normal mucosal carcinogenesis, while the shift of Th17/Treg balance to Treg might involve in the occurrence of normal mucosal cancerization.

Indexed as

Carcinoma, Squamous CellMouth NeoplasmsTh17 CellsTh1 CellsTh2 CellsT-Lymphocytes, Regulatory9,10-Dimethyl-1,2-benzanthraceneAnimalsCarcinogensCell Transformation, NeoplasticCricetinaeMaleMesocricetusMouth MucosaPrecancerous Conditions9,10-Dimethyl-1,2-benzanthraceneCarcinogensHelper t cellImmunological balanceOPMDsOSCC

Identifiers

PMID40898227
PMCPMC12403874

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.