Evidence map›Paper›PMID 40898141›Full record

ArticleBMC musculoskeletal disorders2025

Association between sarcopenia and falls, fractures, hospital readmission, and all-cause mortality in older adults with endocrine disorders: a longitudinal study of aging in China.

Qionglan Zhou, Ying Zhu, Qin Guo, Wei Wang, Ling Wang, Xuejun Zhang, Yan Yang, Lei Zhang, Yiyi Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qionglan Zhou *Department of Endocrinology, People's Hospital of Yilong County, Nanchong, Sichuan, China.
Ying Zhu *Department of Endocrinology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Qin GuoDepartment of Endocrinology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Wei WangDepartment of Endocrinology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Ling WangSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Xuejun ZhangDepartment of Endocrinology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Yan YangDepartment of Endocrinology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Lei Zhang *Department of Endocrinology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China. zhanglei19972023@126.com.
Yiyi Zhang *Department of Endocrinology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China. tibby11@126.com.

Funding

Sichuan Provincial People's Hospital 2020QN04
6 · The paper itself

Abstract

backgroundTo explore whether older adults with sarcopenia are at greater risk for falls, fractures, hospital readmissions, and all-cause mortality compared to those without sarcopenia.

methodsAn elderly population discharged from June 2020 to January 2022 from the Department of Endocrinology of Sichuan Provincial People's Hospital was collected. The cohort included patients with various endocrine disorders, primarily type 2 diabetes mellitus, thyroid dysfunction (hypo- and hyperthyroidism), adrenal insufficiency, and metabolic syndrome. Clinicopathologic data were collected, and sarcopenia was diagnosed based on muscle mass, handgrip strength, and gait speed. Multivariate logistic and Cox regression analyses were performed to identify risk factors for sarcopenia and evaluate its association with adverse outcomes.

resultsAmong 161 participants, 50 (31.06%) had sarcopenia. Sarcopenia significantly increased the risk of falls (adjusted HR: 2.38, 95% CI: 1.06-5.35, P = 0.036) but was not associated with hospital readmissions (adjusted HR: 0.87, 95% CI: 0.49-1.53, P = 0.630), fractures (adjusted HR: 1.01, 95% CI: 0.20-3.92, P = 0.992), or all-cause mortality (adjusted HR: 1.81, 95% CI: 0.49-6.67, P = 0.374). Impaired gait speed was a strong predictor of increased fall risk (adjusted HR: 5.00, 95%CI: 1.27 ~ 19.90, P = 0.022), suggesting that patients who failed the gait speed test were substantially more likely to experience falls, and grip strength was a better predictor of clinical prognosis (adjusted HR: 0.85, 95%CI: 0.77 ~ 0.95, P = 0.004).

conclusionSarcopenia is independently associated with an increased risk of falls in elderly patients with endocrine-related diseases. Recognizing and treating sarcopenia can prevent falls and help improve clinical prognosis in older patients. However, the heterogeneity of underlying endocrine disorders may influence these associations and should be considered in clinical interpretation.

Indexed as

Accidental FallsAgingEndocrine System DiseasesFractures, BonePatient ReadmissionSarcopeniaAgedAged, 80 and overCause of DeathChinaFemaleHand StrengthHumansLongitudinal StudiesMaleMortalityAll-cause mortalityFallsFracturesHospital readmissionRisk factorSarcopenia

Identifiers

PMID40898141
PMCPMC12403857

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.