Evidence map›Paper›PMID 40898139›Full record

ArticleBMC cancer2025

CARBOMETASPINE: protocol for a multicenter, prospective, randomized controlled trial of carbonfiber spinal fixation in metastatic disease.

Kamil Krystkiewicz, Łukasz Kuncman, Magdalena Julita Orzechowska, Beata Pytlarz, Aleksander Kowal, Mateusz Siwak, Jacek Fijuth, Kinga Ranoszek, Mateusz Pajdziński, Katarzyna Zubiel and 3 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06293157 (Carbon Fiber Transpedicular Screws in Treatment of Spinal Metastatic Disease and Stereotactic Radiotherapy - a Prospective, Randomized Trial), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06293157 narecruitingnot on this map

Carbon Fiber Transpedicular Screws in Treatment of Spinal Metastatic Disease and Stereotactic Radiotherapy - a Prospective, Randomized Trial

TypeinterventionalSponsorCopernicus Memorial HospitalRan2023 to 2033Enrolled226ConditionsMetastatic Spinal Cord Compression, Metastasis SpineArmsTranspedicular spinal stabilization - carbon fibers-based implants, Transpedicular spinal stabilization - titanium implants, Stereotactic body radiotherapy
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kamil KrystkiewiczDepartment of Neurosurgery and Neurooncology, Copernicus Memorial Hospital in Lodz, Lodz, Poland. kamil.krystkiewicz@gmail.com.
Łukasz KuncmanDepartment of Radiotherapy, Medical University of Lodz, Lodz, Poland.
Magdalena Julita OrzechowskaDepartment of Molecular Carcinogenesis, Medical University of Lodz, Lodz, Poland.
Beata PytlarzDepartment of Neurosurgery and Neurooncology, Copernicus Memorial Hospital in Lodz, Lodz, Poland.
Aleksander KowalDepartment of Neurosurgery and Neurooncology, Copernicus Memorial Hospital in Lodz, Lodz, Poland.
Mateusz SiwakDepartment of Neurosurgery and Neurooncology, Copernicus Memorial Hospital in Lodz, Lodz, Poland.
Jacek FijuthDepartment of Radiotherapy, Medical University of Lodz, Lodz, Poland.
Kinga RanoszekDepartment of Radiotherapy, Medical University of Lodz, Lodz, Poland.
Mateusz PajdzińskiDepartment of Radiotherapy, Medical University of Lodz, Lodz, Poland.
Katarzyna ZubielDepartment of Neurosurgery and Neurooncology, Copernicus Memorial Hospital in Lodz, Lodz, Poland.
Filip ArczewskiDepartment of Neurosurgery and Neurooncology, Copernicus Memorial Hospital in Lodz, Lodz, Poland.
Karol DziedzicDepartment of Neurosurgery and Neurooncology, Copernicus Memorial Hospital in Lodz, Lodz, Poland.
Marcin TosikDepartment of Neurosurgery and Neurooncology, Copernicus Memorial Hospital in Lodz, Lodz, Poland.

Funding

Polish Medical Research Agency grant no. 2023/ABM/01/00013
6 · The paper itself

Abstract

backgroundSpinal metastases frequently cause neurological compromise and mechanical instability. Titanium fixation limits postoperative imaging and hinders stereotactic body radiotherapy (SBRT) planning because of artefacts.

methodsCARBOMETASPINE is a multicentre, prospective, randomised controlled trial. A total of 226 adults with unstable or epidurally infiltrating spinal metastases will be randomised 1 : 1 : 1 to: (I) carbonfibre/PEEK fixation + postoperative SBRT (5 × 5 Gy); (II) titanium fixation + postoperative SBRT; (III) preoperative SBRT + titanium fixation. The primary endpoint is progressionfree survival of the treated spinal level. Secondary endpoints include dosimetric quality, pain (NRS), surgical complication rates and implant failure. DISCUSSION: Radiolucent carbonfibre implants may improve the geometric accuracy of SBRT planning and enhance local tumour control while preserving mechanical strength. This protocol follows SPIRIT recommendations and will provide robust evidence on clinical benefits and implementation barriers of carbonfibre systems.

trial registrationClinicalTrials.gov, NCT06293157. Registered 17 February 2024.

Indexed as

RadiosurgerySpinal NeoplasmsCarbon FiberHumansMulticenter Studies as TopicProspective StudiesRandomized Controlled Trials as TopicTitaniumCarbon FiberTitaniumCarbon-fiber fixationMetastatic spinal diseaseStereotactic body radiotherapyTranspedicular stabilization

Identifiers

PMID40898139
PMCPMC12403952

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.