Trial reportBMC geriatrics2025
The effect of resistance training for older adults with cognitive frailty: a randomized controlled trial.
Trial report in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Exercise modalities in mild cognitive impairment: a systematic review and network meta-analysis of comparative effectiveness.Frontiers in aging neuroscience · 2026Pooled it
- Impact of exercise intervention on depression, anxiety, sleep and quality of life in patients with cognitive impairment: a systematic review and network meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Exercise Training for Cerebrovascular and Cognitive Health in Adults at Risk of Cognitive Decline: A Scoping Review of Healthcare Translation and Evidence Gaps.Healthcare (Basel, Switzerland) · 2026Review
- Influencing factors of cognitive frailty in older patients with esophageal cancer undergoing chemotherapy: a mixed-methods study.Frontiers in oncology · 2026Article
- Association between physical exercise and cognitive frailty among community-dwelling older adults: the mediating role of self-efficacy.Frontiers in public health · 2026Article
- Microglia in Brain Aging and Age-Related Diseases: Friends or Foes?International journal of molecular sciences · 2025Review
- The impact of exercise interventions on cognitive frailty: a scoping review of outcomes and biological mechanisms.Frontiers in public health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundCognitive decline and the progression to dementia are hastened in individuals with cognitive frailty. Exercise interventions benefit cognitive function in patients with Mild Cognitive Impairment (MCI) or frailty. While the optimal implementation of resistance training for cognitive frailty is still being explored. The aims of this study were to develop and evaluate the effect of a novel, hybrid online-offline resistance training regimen for the cognitive frailty cohort.
methodsIn this single-blind, randomized controlled trial, 68 individuals with MCI and frailty or pre-frailty were enrolled and allocated to either a resistance training program or a standard senior fitness exercise regimen. The resistance training, designed based on the intervention mapping framework, comprised a 12-week hybrid intervention, blending online and offline sessions, conducted three times a week. The primary outcomes measured were global cognitive function and physical function. Data analysis was conducted meticulously using covariance analysis, with a commitment to the intention-to-treat principle.
resultsThe hybrid online-offline resistance training regimen was both safe and feasible. Participants in the resistance training group exhibited significantly greater improvements in global cognitive function as measured by MoCA (F = 6.289, p = 0.011) and 4-meter walk time (F = 10.951, P = 0.002), with least squares mean difference of 1.299 (95% CI: 0.306 to 2.291) and - 0.576 (95% CI: -0.924 to -0.228), and with effect size of 0.095, 1.114, respectively. Furthermore, resistance training proved more effective in boosting attention and enhancing quality of life. Between the groups, no significant differences were noted in executive, language, and memory functions, as well as in measures of anxiety, depression, and self-efficacy, among other aspects.
conclusionsOur study demonstrated that a hybrid online-offline resistance training model is safe and effective for older people with cognitive frailty, providing modest benefits over traditional exercises in enhancing global cognitive function, attention, physical function, and quality of life.
trial registrationChiCTR2100043826 was registered on 4 March 2021.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.