ArticleBMC psychiatry2025
Predictors of clinical trial discontinuation in trichotillomania: a secondary analysis of previous clinical trials.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
2 authors.
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Abstract
backgroundParticipant discontinuation is a significant challenge in pharmacological trials for trichotillomania (hair-pulling disorder). Attrition in clinical trials reduces statistical power, introduces error, and potentially wastes financial and medical resources. Identifying predictors of discontinuation may help researchers enhance participant retention and improve study outcomes.
methodsData from five completed pharmacological trials for trichotillomania were aggregated, and participants were classified as either Discontinued or Completed. Differences in demographic and clinical variables between these groups were analyzed using a generalized linear mixed model.
resultsOf the 222 participants, 177 (80%) were categorized as the Completed group. Discontinued patients (20%) were more likely to have achieved higher levels of formal education and were more likely to have a history of depression.
conclusionsThis study is among the first to examine variables associated with discontinuation rates in trichotillomania trials. The results underscore the importance of addressing educational background and patient history of depression when assessing dropout risk. These findings can guide future research to better support participants at risk of discontinuing treatment.
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