ArticleBMC cancer2025
A subgroup analysis of locally advanced nasopharyngeal carcinoma patients with small lymph nodes and large nodes using adaptive radiotherapy.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
backgroundTo investigate the anatomical and dosimetric differences in target areas and organs at risk (OARs) after adjusting the radiotherapy schedule for nasopharyngeal carcinoma (NPC).
methodsIn total, 34 patients who underwent radiotherapy for NPC were selected. A new localization computed tomography (CT) scan was performed after 25th and before 26th fraction. The target area and organs at risk were redrawn based on the new CT, and the radiotherapy plan was redesigned for the seven remaining rounds of radiotherapy. Plan
resultsIn the re-scan CT, the volume of Planning Target Volume for Nodal Region Right (PTVnd (R)), Planning Target Volume for Nodal Region Left (PTVnd (L)), left parotid and right parotid decreased significantly (P < 0.05). Additionally, the centroids of the left and right parotid moved towards the centre, abdomen and head. Compared to Plan
conclusionsDue to significant anatomical changes in the volume and position of both target volumes and organs at risk during the later fractions of radiotherapy for NPC, the dose coverage of lymph-node regions can no longer meet clinical requirements. Adaptive radiotherapy ensures adequate target coverage while simultaneously reducing the dose to surrounding critical structures.
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