Evidence map›Paper›PMID 40898085›Full record

ArticleBMC gastroenterology2025

Coagulation markers as independent predictors of colorectal cancer aggressiveness.

Hanaa Ali El-Sayed, Doaa H Sakr, Mostafa Abdelhakiem, Mohamed Awad Ebrahim, Maha Othman, Hanan Azzam

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In one paragraph

Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hanaa Ali El-SayedClinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt. Hanaaali269@gmail.com.ORCID http://orcid.org/0009-0005-2780-1232
Doaa H SakrOncology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Mostafa AbdelhakiemOncology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Mohamed Awad EbrahimOncology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Maha OthmanClinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Hanan AzzamClinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is frequently associated with thrombosis with thrombotic events, such as deep vein thrombosis or pulmonary embolism, often correlate with poor clinical outcomes. Coagulation markers have been suggested as potential prognostic indicators for CRC severity. However, the relationship with clinicopathological characteristics in CRC remains unclear. PURPOSE: This study aims to examine the relationship between routine coagulation markers and clinicopathological characteristics in CRC patients. PATIENTS AND

methodsA retrospective analysis was conducted on 100 patients with confirmed diagnosis of CRC, classified according to the 2018 edition of the American Joint Committee on Cancer Tumor/Node/Metastasis staging system for malignant tumors. Clinicopathological characteristics and routine coagulation tests including prothrombin time, and international normalized ratio, activated partial thromboplastin time, prothrombin activity, thrombin time, fibrinogen, d-dimer, platelet count, were evaluated. Spearman correlation was used to assess correlations with clinicopathological characteristics. Additionally, univariate and multivariate ordinal regression analysis were conducted to detect the independent predictors for CRC aggressiveness.

resultsOur data documents several associations between coagulation markers and cancer progression markers. Specifically, positive correlations were identified between fibrinogen and d-dimer levels and each of the following: carcinoembryonic antigen, carbohydrate antigen, tumor stage, node involvement, and metastasis. Regression analysis showed, d-dimer (OR = 1.102, p < 0.001) and fibrinogen (OR = 1.002, p < 0.001) are independent predictors of high-risk CRC cases.

conclusionFibrinogen and d-dimer may serve as independent predictive biomarkers for CRC aggression. Their clinical utility could support personalized treatment plans for CRC patients.

Indexed as

Colorectal NeoplasmsFibrin Fibrinogen Degradation ProductsFibrinogenAdultAgedAntigens, Tumor-Associated, CarbohydrateBiomarkers, TumorBlood Coagulation TestsCarcinoembryonic AntigenDisease ProgressionFemaleHumansMaleMiddle AgedNeoplasm StagingPrognosisAntigens, Tumor-Associated, CarbohydrateBiomarkers, TumorCarcinoembryonic AntigenFibrin Fibrinogen Degradation Productsfibrin fragment DFibrinogenColorectal cancerD-dimerFibrinogenHemostasisProthrombin time

Identifiers

PMID40898085
PMCPMC12403284

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.