Acute versus acute-on-chronic liver failure: comparative analysis of clinical outcomes in Beijing, China.

Hebing Guo, Ningning Yin, Jingyuan Liu, Ang Li

Abstract readComparative Study

In one paragraph

Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hebing GuoDepartment of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Chaoyang District, Beijing, 100015, China.

Ningning YinDepartment of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Chaoyang District, Beijing, 100015, China.

Jingyuan LiuDepartment of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Chaoyang District, Beijing, 100015, China. dtyyicu@ccmu.edu.cn.

Ang LiDepartment of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Chaoyang District, Beijing, 100015, China. liang@ccmu.edu.cn.

Funding

Beijing Research Ward Excellence Program BRWEP2024W102170109National clinical key specialty construction project and Capital health development research project 2023-NO.492

6 · The paper itself

Abstract

backgroundAcute liver failure (ALF) and acute-on-chronic liver failure (ACLF) pose significant threats to patient outcomes, frequently resulting in multiple organ dysfunction syndrome (MODS) and elevated mortality rates. This study investigates MODS outcomes among ALF and ACLF patients in China, identifying key factors that influence mortality and prognosis.

methodsA retrospective cohort analysis was conducted at a specialized tertiary hospital in Beijing, covering the period from June 2009 to May 2022, which included 585 patients:195 with ALF and 390 with ACLF.

resultsAmong these, 61% of ALF patients and 45.1% of ACLF patients developed MODS. ALF patients exhibited a higher incidence of organ failures and significantly higher median admission critical illness scores. Multivariate logistic regression analysis identified age, number of organ failures, and platelet count as independent predictors of 90-day mortality. Kaplan-Meier survival hazards analysis revealed significantly higher 90-day cumulative mortality rates for ALF patients compared to ACLF patients (33.8% vs. 25.9%, p = 0.009).

conclusionApproximately 50% of liver failure patients progress to MODS, with ALF patients demonstrating a higher incidence of MODS and poorer 90-day prognoses.

Indexed as

Acute-On-Chronic Liver FailureLiver Failure, AcuteMultiple Organ FailureAdultBeijingChinaFemaleHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedPrognosisRetrospective StudiesAcute liver failureAcute-on-chronic liver failureClinical outcomesCohort studyMultiple organ dysfunction syndrome

Identifiers

PMID40898073

DOI10.1186/s12876-025-04234-x

PMCPMC12406371

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.