Evidence map›Paper›PMID 40898067›Full record

ArticleBMC neurology2025

Safety and outcome of intravenous thrombolysis in ischemic stroke related to intracranial artery dissection.

Wen Yang, Jian-Wei Wang, Mei-Xia Zhang, Hong-Fang Chen

Abstract readCase Reports
In one paragraph

Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wen YangDepartment of Neurology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine(formerly Jinhua Municipal Central Hospital), No.365 Renmin East Road, Jinhua, 321000, Zhejiang Province, China.
Jian-Wei WangDepartment of Neurology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine(formerly Jinhua Municipal Central Hospital), No.365 Renmin East Road, Jinhua, 321000, Zhejiang Province, China.
Mei-Xia ZhangDepartment of Neurology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine(formerly Jinhua Municipal Central Hospital), No.365 Renmin East Road, Jinhua, 321000, Zhejiang Province, China.
Hong-Fang ChenDepartment of Neurology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine(formerly Jinhua Municipal Central Hospital), No.365 Renmin East Road, Jinhua, 321000, Zhejiang Province, China. jhchf894@163.com.

Funding

Jinhua Science and Technology Bureau 2024-4-081
6 · The paper itself

Abstract

backgroundThe clinical efficacy of intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) associated with intracranial artery dissection (IAD) remains uncertain. This study presents a case of basilar artery dissection (BAD) in a 57-year-old Asian female patient devoid of previous risk factors for stroke who experienced a sudden onset of consciousness disturbance. The patient's clinical condition deteriorated during IVT administration, but subsequent medical intervention and rehabilitative exercises facilitated eventual recovery of daily functioning. MRI eventually identified the etiology of the patient's AIS.

conclusionAIS related to anterior circulation IAD may pose a relatively high risk of hemorrhagic transformation and symptom exacerbation during the early stages of IVT, but the impact on long-term prognosis remains uncertain. Consequently, further investigation is warranted to assess the safety and efficacy of IVT in such patients.

Indexed as

Aortic DissectionFibrinolytic AgentsIntracranial AneurysmIschemic StrokeThrombolytic TherapyTissue Plasminogen ActivatorAdministration, IntravenousFemaleHumansMiddle AgedTreatment OutcomeFibrinolytic AgentsTissue Plasminogen ActivatorAcute ischemic strokeBasilar artery dissectionIntracranial artery dissectionIntravenous thrombolysisRt-PA

Identifiers

PMID40898067
PMCPMC12406453

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.