ArticleBMC infectious diseases2025
Development of paper-based electrochemiluminescence test strips for pathogenic microorganisms.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Electrochemical Lateral Flow Platforms: Pioneering the Future of Rapid Testing.Molecules (Basel, Switzerland) · 2026Review
- Exploring the Feasibility of Paper-Based Substrates for User-Friendly Electrochemiluminescent Sensors.Analytical chemistry · 2026Article
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Authors and funding
7 authors.
Funding
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Abstract
backgroundA novel paper-based electrochemiluminescence test strip (ECL-TS) for the detection of pathogenic microorganisms is developed by combining lateral flow immunochromatography(LFIC) with ECL.
methodsBased on the principle of double-antibody sandwich, monoclonal antibody 1 labeled with tris(bipyridine)ruthenium is fixed on the conjugate pad as the labeled antibody, and monoclonal antibody 2 is directly fixed on the detection pad as the capture antibody. The antibody is Made to flow to the detection region through LFIC and specifically bind to the capture antibody in the detection region. Cyclic voltammetry scanning is carried out at a speed of 0.1 V/s in the detection region to obtain an ECL signal, which is then converted into the content of the virus in the sample to be tested.
resultsUnder the optimized conditions, the developed test strip could be detected within 5 min, with a minimum detection Limit of 7.96 pg/mL, a reproducibility deviation of 5.62%, a stability deviation of 6.34%, and a KAPPA value of 0.88, which was specific for the related viruses.
conclusionsThe developed paper-based ECL-TS provides a portable, rapid and sensitive detection method. Taking the novel coronavirus (SARS-CoV-2) as an example, compared with the nucleic acid detection method, this method has the advantages of being rapid, accurate and low-cost. It is expected to be used as a point-of-care testing (POCT) tool in the detection of pathogenic microorganisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.