Evidence map›Paper›PMID 40898034›Full record

ArticleBMC plant biology2025

Deciphering metabolic regulation in overripe grapes through multi-omics analysis of non-targeted metabolome, proteome, and transcriptome.

Ning Shi, Jing Cheng, Xiao-Tong Gao, Hao-Cheng Lu, Meng-Bo Tian, Ming-Yu Li, Chang-Qing Duan, Jun Wang

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In one paragraph

Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Decoding the Functional Proteome ofPlants (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ning Shi *Center for Viticulture and Enology, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Jing Cheng *Center for Viticulture and Enology, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Xiao-Tong GaoCenter for Viticulture and Enology, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Hao-Cheng LuCenter for Viticulture and Enology, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Meng-Bo TianCenter for Viticulture and Enology, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Ming-Yu LiCenter for Viticulture and Enology, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Chang-Qing DuanCenter for Viticulture and Enology, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Jun WangCenter for Viticulture and Enology, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China. jun_wang@cau.edu.cn.

Funding

China Agriculture Research System of MOF and MARA CARS-29Funded by Basic Research Program of Jiangsu BK20230297Major Science and Technology Special Projects of Xinjiang Uygur Autonomous Region during the "14th Five-year Plan" 2022A02002-1
6 · The paper itself

Abstract

backgroundAs climate warms, the sugars and secondary metabolites in grapes gradually become uncoupled during development, resulting in the phenomenon of overripe fruit becoming more frequent around the world, especially in some arid regions. However, the key metabolic regulations to grape overripening are still poorly understood. To address this, we conducted a multi-omics study on Cabernet Sauvignon overripe berries over two years, analyzing the non-targeted metabolome, transcriptome, and proteome, aiming to provide a theoretical basis for delayed harvest strategies based on grape quality.

resultsThe delayed harvests caused significant changes in berry transcriptome and proteome. Genes and proteins responding to environmental changes were up-regulated, while those related to metabolism were down-regulated, indicating the primary function of berries during the overripening stage shifted away from extensive metabolite synthesis. The key enzyme genes and proteins linked to changes in metabolites like glucose, pyruvate, malate, alanine, γ-aminobutyric acid, and resveratrol, were identified.

conclusionsIn hot regions, the overripening stage of grape berries may be detrimental to their quality. This study highlights the core molecular changes during grape overripening and offer valuable insights for optimizing grape harvest date.

Indexed as

FruitMetabolomeProteomeTranscriptomeVitisGene Expression Regulation, PlantMetabolomicsMultiomicsPlant ProteinsProteomicsPlant ProteinsProteomeMulti-omics analysisOverripeningProteomeTranscriptome

Identifiers

PMID40898034
PMCPMC12403331

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.