SynthesisAesthetic plastic surgery2025
Advances of Hyaluronic Acid Nasal Injection Techniques and Complications: A Systematic Review.
Synthesis in Aesthetic plastic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe increased demand for non-surgical rhinoplasty using hyaluronic acid (HA) has given impetus to explore more injection techniques and has also placed a higher demand on the coping of complications.
objectivesThe purpose of this systematic review is to provide clinicians with recommendations by broadly consolidating data on HA injections for rhinoplasty injection techniques and complications, and presenting the advantages and disadvantages of each technique and the treatment of complications.
methodsA systematic electronic literature search using keywords and MESH search terms over the PubMed/Medline, Cochrane Central, Embase, Web of Science, and CNKI online databases was conducted from 2000 to 2024. Risk of bias assessment was performed for all included articles.
resultsThere were 37 papers with a total of 7339 patients included in the study. Four different injection regimens were summarized. The incidence of serious complications such as blindness, skin necrosis, and cerebral infarction was only 3‰. Mild complications including bruising, hematoma, edema, and asymmetry had a higher incidence of 13.34%.
conclusionExisting techniques for hyaluronic acid nasal injections can be summarized as top-to-bottom approach, bottom-up approach, critical site injections, and multi-plane injections, with the latter two more innovative injections reporting higher complication rates in comparison. LEVEL OF EVIDENCE I: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
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