Evidence map›Paper›PMID 40897942›Full record

ArticleAnnals of surgical oncology2026

Social Vulnerability as a Neighborhood-Level Determinant of Pancreatic Cancer Survivorship: A National Analysis of Veterans Affairs Patients.

Sabran J Masoud, Alex J Bartholomew, Michael E Lidsky, Daniel P Nussbaum, Dan G Blazer, Leila Mureebe, Christopher R Mantyh, Peter J Allen, Allison N Martin

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Sabran J MasoudDepartment of Surgery, Duke University Medical Center, Durham, NC, USA. sabran.masoud@duke.edu.ORCID http://orcid.org/0000-0002-7758-3545
Alex J BartholomewDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.
Michael E LidskyDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.
Daniel P NussbaumDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.
Dan G BlazerDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.
Leila MureebeDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.
Christopher R MantyhDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.
Peter J AllenDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.
Allison N MartinDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVeterans Affairs (VA) patients participate within the largest USA equal-access healthcare system, though still experience cancer mortality disparities by social determinants. The Social Vulnerability Index (SVI)-measuring community poverty, minority status, housing, and transportation-has delineated gradients in cancer care utilization and outcomes. We therefore assessed relationships between SVI and mortality in veterans with pancreatic ductal adenocarcinoma (PDAC). PATIENTS AND

methodsRecords of patients with stage I-III PDAC diagnosed January 2005-December 2018 were abstracted from the VA Corporate Data Warehouse. Addresses were geocoded to SVI. Mann-Whitney U and chi-squared tests compared baseline characteristics. Overall survival (OS) was compared using Kaplan-Meier and multivariable Cox proportional hazards methods.

resultsA total of 1778 patients were evaluated, of which 570 (32%) underwent surgical resection. A total of 516 (29%) patients originated from census tracts in the highest SVI quartile. These patients were more likely Black (38% vs 13%), unemployed (49% vs 35%), and metropolitan-based (87% vs 76%; all p < 0.001). Over a median follow-up of 8.7 months, median OS was 9.5 months versus 10.2 months for high and low SVI groups, respectively (log-rank p = 0.03). In the resected cohort, high and low SVI groups reflected a median OS of 18.2 months versus 23.1 months, respectively (log-rank p < 0.01). High SVI remained independently associated with mortality for resected patients only (hazard ratio [HR] 1.4, p < 0.01).

conclusionsHigh SVI was associated with poorer prognosis after PDAC resection. Acknowledging a need to identify mechanisms, SVI has potential use in triaging PDAC survivorship interventions in veterans.

Indexed as

Carcinoma, Pancreatic DuctalNeighborhood CharacteristicsPancreatic NeoplasmsSocial VulnerabilitySurvivorshipVeteransAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesSocial Determinants of HealthSurvival RateCancerGeospatialPancreasSocial vulnerabilityVeterans

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.