Evidence map›Paper›PMID 40897935›Full record

ReviewDiscover oncology2025

Advances of androgen receptor in triple-negative breast cancer: from molecular mechanisms to clinical applications.

Lange Ma, Hao Xu, Chunyan Wang, Yue Hu, Qinglan Ren, Shengnan Yu

Abstract readReview
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Genomic Alterations in Quadruple-Negative Breast Cancer Tumors.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lange MaDepartment of Oncology, Laboratory of Immunity, Inflammation & Cancer, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Hao XuDepartment of Oncology, Laboratory of Immunity, Inflammation & Cancer, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Chunyan WangDepartment of Oncology, Laboratory of Immunity, Inflammation & Cancer, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Yue HuDepartment of Oncology, Laboratory of Immunity, Inflammation & Cancer, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Qinglan RenDepartment of Oncology, Laboratory of Immunity, Inflammation & Cancer, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. renqlwu@163.com.
Shengnan YuDepartment of Oncology, Laboratory of Immunity, Inflammation & Cancer, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. 1334870996@qq.com.

Funding

National Outstanding Youth Science Fund Project of National Natural Science Foundation of China Grant No. 82203007the China Postdoctoral Science Foundation No.2023MD744162
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is a clinically aggressive malignancy with high heterogeneity at molecular and genetic levels, which characterized by the absence of effective therapeutic targets and marked resistance to conventional chemotherapy regimens. The androgen receptor (AR) is highly expressed by TNBC tumor cells and plays a vital role on tumor progression. With more research into AR signaling pathways and functions, AR-targeted therapy is becoming a promising treatment strategy. This review synthesizes emerging evidence in AR-related preclinical research and clinical outcomes, including monotherapy and combined strategies based on AR-targeted treatment. Through the comprehensive review, we hope to find novel therapeutic insights for TNBC.

Indexed as

Androgen receptorAndrogen receptor inhibitorsCombination treatmentTriple-negative breast cancer

Identifiers

PMID40897935
PMCPMC12405098

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.