SynthesisSurgical endoscopy2025
Enucleation for insulinoma: consolidating evidence through systematic review and meta-analysis.
Synthesis in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Endoscopic ultrasound-guided radiofrequency ablation of pancreatic insulinoma.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2026Pooled it
- Recurrent Syncope, Behavioral Changes and Weight Gain in an Elderly Filipino Woman: Successful Diagnosis and Management of Insulinoma With 13-Year Disease-Free Follow-up.Journal of the ASEAN Federation of Endocrine Societies · 2026Article
- Laparoscopic Localization and Enucleation of Multiple Insulinomas Using a Combination of Indocyanine Green Fluorescence Imaging and Intraoperative Ultrasound.Annals of surgical oncology · 2026Article
- A 30-year institutional experience of insulinoma management at a tertiary care center: a case series.Gland surgery · 2026Article
- Recurrent Hypoglycemia Secondary to Pancreatic Insulinoma.Kansas journal of medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPancreas-preserving procedures such as enucleation (EN) are indicated for select patients with insulinomas. Despite the increasing popularity of EN, no consensus has been reached on the preferred surgical approach for the management of insulinomas. The aim of this meta-analysis of proportions is to evaluate the safety and efficacy of EN for patients with pancreatic insulinoma.
methodsCochrane, Embase, PubMed, Scopus, and Web of Science were searched from database inception to December 2023. The pooled mean and proportions were analyzed using a random-effects model. The review was registered prospectively with PROSPERO (CRD42024492786).
resultsTwenty-one studies with 803 patients met the inclusion criteria. The pooled mean tumor diameter was 1.5 cm (95%CI: 1.3-1.6). The pooled mean operative time was 142 min (95%CI: 118-166), postoperative hospital stay was 9.5 days (95% CI: 7.2-11.7), and estimated blood loss (EBL) was 71.3 mL (95% CI: 47.3-95.3). The overall postoperative occurrence rate was 37.3% (95%CI: 0.264-0.481, I
conclusionEN appears safe and effective in managing pancreatic insulinoma for selected patients, with low rates of grade C POPF and recurrence. Despite the promising results, more selective criteria based on the location of insulinoma with a larger sample size and extended follow-up periods are necessary to ascertain the safety and efficacy of the treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.