Evidence map›Paper›PMID 40897875›Full record

SynthesisSurgical endoscopy2025

Impact of myotomy length on per-oral endoscopic myotomy (POEM) outcomes for achalasia: a meta-analysis of randomized trials.

Yizhong Wu, Alexander Grieme, Manuel Garza, Eric R Smith, Azizullah Beran, Bryce Bushe, Andrew Han, Abdulrahman Qatomah, Marco Spadaccini, Alberto Tringali and 4 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yizhong WuDepartment of Internal Medicine, Baylor Scott & White Medical Center - Round Rock, Round Rock, TX, USA.
Alexander GriemeDepartment of Internal Medicine, Baylor Scott & White Medical Center - Round Rock, Round Rock, TX, USA.
Manuel GarzaDivision of Gastroenterology, Baylor Scott & White Medical Center - Round Rock, Round Rock, TX, USA.
Eric R SmithDepartment of Internal Medicine, Baylor Scott & White Medical Center - Round Rock, Round Rock, TX, USA.
Azizullah BeranDivision of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN, USA.
Bryce BusheDivision of Gastroenterology, Baylor Scott & White Medical Center - Round Rock, Round Rock, TX, USA.
Andrew HanDivision of Gastroenterology, South Texas VA, San Antonio, TX, USA.
Abdulrahman QatomahDivision of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Marco SpadacciniEndoscopy Unit, Humanitas Clinical Center - IRCCS, Rozzano, Italy.
Alberto TringaliDepartment of Digestive Endoscopy and Gastroenterology, AULSS2, Conegliano Hospital, Conegliano, Italy.
Lumír Kunovský2nd Department of Internal Medicine - Gastroenterology and Geriatrics, University Hospital Olomouc, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.
Mohammad A Al-HaddadDivision of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN, USA.
Hiroyuki AiharaDivision of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Daryl RamaiDivision of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. darylramai@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPeroral endoscopic myotomy (POEM) has been established as a safe and effective intervention for Type I and II achalasia. Studies have shown that short POEM is non-inferior to long POEM, with some evidence of decreased incidence of gastroesophageal reflux disease (GERD). This meta-analysis aims to systematically review and analyze randomized controlled trials (RCTs) data comparing clinical and safety outcomes for long and short POEM procedures while further investigating differences in GERD and other long-term clinical outcomes.

methodsWe conducted a comprehensive search in PubMed, Embase, Cochrane, and Web of Science from inception until October 2024 for RCTs comparing long and short POEM procedures for the treatment of achalasia. Our pooled data was analyzed for clinical and objective procedural success, procedural adverse events, GERD outcomes, procedure time, and hospitalization time. A random effects model was used, and the data was presented using pooled odds ratios (OR) and mean differences (MD) with 95% confidence intervals (CI).

resultsFive RCTs were included with 518 achalasia patients (253 in short group and 265 in long group). Baseline characteristics of enrolled patients were similar across studies. Short and long POEM had similar clinical success (OR 1.18, 95% CI: 0.45-3.06, p = 0.73, I

conclusionOur study demonstrates that short POEM is clinically non-inferior to long POEM but has advantages in shorter procedure time and lower odds of objective evidence of gastroesophageal reflux disease.

Indexed as

Esophageal AchalasiaMyotomyNatural Orifice Endoscopic SurgeryPyloromyotomyGastroesophageal RefluxHumansOperative TimePostoperative ComplicationsRandomized Controlled Trials as TopicTreatment OutcomeAchalasiaEndoscopyMyotomyPOEMReflux

Identifiers

PMID40897875

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.