Evidence map›Paper›PMID 40897790›Full record

ArticleCommunications biology2025

A-to-I edited SNHG3 promotes non-small cell lung cancer metastasis by promoting fatty acid oxidation and resisting ferroptosis.

Shizhen Chen, Amei Zhuo, Renyu Tang, Siming Su, Binbin Wen, Wujun Wei, Jianjiang Xie, Ziqi Yu, Boqi Rao, Jiachun Lu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. LncRNA SNHG3: a potential biomarker for human diseases.Frontiers in cell and developmental biology · 2026
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shizhen Chen *The Key Laboratory of Advanced Interdisciplinary Studies, School of Public healthy, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Amei Zhuo *The Key Laboratory of Advanced Interdisciplinary Studies, School of Public healthy, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Renyu Tang *The Key Laboratory of Advanced Interdisciplinary Studies, School of Public healthy, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Siming SuThe Key Laboratory of Advanced Interdisciplinary Studies, School of Public healthy, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Binbin WenThe Key Laboratory of Advanced Interdisciplinary Studies, School of Public healthy, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Wujun WeiKey Laboratory of Clinical Molecular Diagnosis and Research for High Incidence Diseases in Western Guangxi Universities, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Jianjiang XieDepartment of Pulmonary and Critical Care Medicine, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Ziqi YuThe Key Laboratory of Advanced Interdisciplinary Studies, School of Public healthy, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Boqi RaoThe Key Laboratory of Advanced Interdisciplinary Studies, School of Public healthy, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Jiachun LuThe Key Laboratory of Advanced Interdisciplinary Studies, School of Public healthy, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.ORCID http://orcid.org/0000-0002-9999-7220
Yibin DengKey Laboratory of Clinical Molecular Diagnosis and Research for High Incidence Diseases in Western Guangxi Universities, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China. yibin.deng@ymcn.edu.cn.
Zhili ZhangState Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. zhangzili_04@163.com.ORCID http://orcid.org/0000-0002-8544-2339
Lei YangThe Key Laboratory of Advanced Interdisciplinary Studies, School of Public healthy, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. leiyang@gzhmu.edu.cn.ORCID http://orcid.org/0000-0002-1315-7651

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82373120, 81871876Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2024A1515013256
6 · The paper itself

Abstract

Adenosine-to-inosine (A-to-I) RNA editing is a critical post-transcriptional modification that enhances tumor genome diversity and contributes to cancer progression. In non-small cell lung cancer (NSCLC), while specific A-to-I editing events have been identified, their functional mechanisms and clinical relevance remain poorly understood. Here, through whole-transcriptome analysis of NSCLC specimens, we discovered a hyper-editing event at position c.1746 in the long non-coding RNA SNHG3 (c.1746 A > I), which correlates with advanced metastatic stages and reduced patient survival. Functional studies demonstrated that edited SNHG3 (SNHG3

Indexed as

Adenosine DeaminaseCarcinoma, Non-Small-Cell LungLung NeoplasmsRNA-Binding ProteinsRNA EditingRNA, Small NucleolarAnimalsAntineoplastic AgentsBiomarkers, TumorDNA-Binding ProteinsDocetaxelDrug Resistance, NeoplasmFatty AcidsFerroptosisHeterograftsHigh Mobility Group ProteinsADAR protein, humanAdenosine DeaminaseAntineoplastic AgentsBiomarkers, TumorDNA-Binding ProteinsDocetaxelFatty AcidsHigh Mobility Group ProteinsPalmitic AcidRNA-Binding ProteinsRNA, Small NucleolarSSRP1 protein, humanTranscriptional Elongation Factors

Identifiers

PMID40897790
PMCPMC12405545

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.