ArticleInvestigative and clinical urology2025
Aquablation versus HoLEP: Propensity score matching analysis of functional outcomes and ejaculation preservation.
Article in Investigative and clinical urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Aquablation versus laser enucleation of the prostate for benign prostatic hyperplasia: a systematic review and pairwise meta-analysis of head-to-head studies including the first randomized trial.Frontiers in surgery · 2026Pooled it
- Phase-specific workflow maturation during early institutional implementation of Aquablation for benign prostatic hyperplasia: a retrospective single-center study.Journal of robotic surgery · 2026Article
- Factors predicting the success of ejaculation preserving transurethral resection of the prostate: a prospective cohort study.Prostate international · 2026Article
- The impact of prostate size on outcomes of aquablation: a prospective study.World journal of urology · 2026Article
- The learning curve of waterjet ablation of the prostate: a cumulative sum analysis of surgical and functional outcomes.World journal of urology · 2026Article
- Holmium laser enucleation of the prostate versus transurethral resection of the prostate for benign prostatic hyperplasia: evidence from a Korean retrospective analysis using the Common Data Model.Prostate international · 2026Article
- Quality-of-life outcomes following Aquablation in men with poor initial quality of life: pooled analysis of five international studies.Prostate international · 2026Article
- Holmium laser enucleation of the prostate (HoLEP): a narrative review of sexual side effects.Translational andrology and urology · 2026Review
- Letter to the editor: Aquablation versus HoLEP: Propensity score matching analysis of functional outcomes and ejaculation preservation.Investigative and clinical urology · 2026Article
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No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to compare the clinical outcomes of Aquablation and Holmium Laser Enucleation of the Prostate (HoLEP) for the treatment of benign prostatic hyperplasia (BPH), with emphasis on functional improvement, ejaculatory preservation, and perioperative safety. MATERIALS AND
methodsWe retrospectively analyzed data from January 2023 to March 2024, excluding patients with follow-up shorter than 3 months. Propensity score matching was performed using age, prostate volume, and preoperative prostate-specific antigen (PSA). Pre- and postoperative outcomes included International Prostate Symptom Score, Overactive Bladder Symptom Score, maximum flow rate (Qmax), post-void residual urine volume (PVR), PSA, and MSHQ-EjD (Male Sexual Health Questionnaire-Ejaculatory Dysfunction)-based ejaculatory grading (0-3). Paired t-tests, Wilcoxon signed-rank tests, McNemar's test, and Mann-Whitney U test were applied as appropriate.
resultsA total of 104 patients were included, with 34 matched pairs. Both procedures significantly improved lower urinary tract symptoms, with no significant differences in symptom score changes or PVR. HoLEP resulted in greater improvements in Qmax and PSA (p=0.011 and p<0.001, respectively). Aquablation demonstrated significantly better preservation of ejaculation (p=0.002). Although transient incontinence was more frequent in HoLEP and gross hematuria and urinary retention were more common in Aquablation, none of the complication rates showed statistically significant differences.
conclusionsAquablation and HoLEP are both effective surgical options for BPH. Aquablation offers comparable symptom relief with significantly superior ejaculation preservation, making it particularly suitable for sexually active patients. HoLEP provides greater deobstructive efficacy, as evidenced by superior Qmax and PSA outcomes. These findings support individualized, patient-centered decision-making.
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