ArticleThe journal of prevention of Alzheimer's disease2025
Prevalence and co-occurrence of dementia risk factors in Denmark: A nationwide study.
Article in The journal of prevention of Alzheimer's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Rethinking dementia prevention for a continuum of risk.Nature reviews. Neurology · 2026Article
- Differences in the prevalence and patterns of dementia risk factors across 14 countries and regions: a harmonised cross-national analysis.The lancet. Healthy longevity · 2026Article
- Observational
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Authors and funding
10 authors.
Funding
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Abstract
backgroundThe clustering of dementia risk factors is common and has implications for policies targeting risk reduction.
objectivesTo estimate the prevalence of 16 dementia risk factors and their co-occurrence.
designCross-sectional based on a closed cohort on 1 January 2022 with nationwide data on risk factors from 1969/1977.
settingDenmark
participantsWhole population; closed cohort of individuals ≥65 years on 1 January 2022, and a subpopulation of responders in the 2010/2013 Danish National Health Survey. INTERVENTION (EXPOSURES): Sixteen dementia risk factors: hypertension, cardiovascular disease, diabetes, hypercholesterolemia, obesity, smoking, alcohol, physical inactivity, depression, hearing loss, vision impairment, traumatic brain injury, sleep disorders, hospital-diagnosed infections, social isolation, and low education. MEASUREMENTS: Period and point prevalence proportions of the dementia risk factors and of all possible combinations of factors (those occurring in ≥10 % of individuals). The prevalence estimates reflect a population-level view of persons who have experienced, were diagnosed, or were treated for the risk factors assessed.
resultsIn the whole population (N = 1,214,286) and the subpopulation (N = 88,565), 5 % had no risk factors, 12 % had only one, and 82 % had multiple. Hypertension was the most prevalent (57 %), and vision impairment the least (2 %). Men, individuals ≥85 years, and those with low education had the highest prevalence of risk factors (with exceptions).
conclusionsClustering of risk factors is very common, and findings emphasize the need to focus on multidomain interventions for dementia risk reduction that account for the clustering of risk.
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