Evidence map›Paper›PMID 40897474›Full record

Observational studyBMJ open2025

Assessing the global variation in patient characteristics, management and short-term outcomes of spontaneous intracranial haemorrhage worldwide: a protocol for a global observational prospective multicentre study (the PLOT-ICH study).

Sara Venturini, David Clark, Brandon George Smith, Laura Hobbs, Michael F Bath, Harry Mee, Megan Still, Saniya Mediratta, Mohamed Amin Soliman, Katharina Kohler and 24 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06731751 (A Prospective, International Observational Study Assessing the Global Variation in Patient Characteristics, Management and Outcomes of Spontaneous Intracranial Haemorrhage.), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06731751 not yet recruitingnot on this map

A Prospective, International Observational Study Assessing the Global Variation in Patient Characteristics, Management and Outcomes of Spontaneous Intracranial Haemorrhage.

TypeobservationalSponsorUniversity of CambridgeRan2025 to 2026Enrolled1,000ConditionsStroke, Intracerebral Haemorrhage, Subarachnoid Haemorrhage (SAH)ArmsManagement of spontaneous intracranial haemorrhage
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Sara VenturiniNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK sv465@cam.ac.uk.ORCID http://orcid.org/0000-0002-9541-0090
David ClarkNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.
Brandon George SmithNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-8471-1368
Laura HobbsNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.
Michael F BathNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1879-1093
Harry MeeNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.
Megan StillDepartment of Neurosurgery, University of Florida, Gainesville, Florida, USA.
Saniya MedirattaNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.
Mohamed Amin SolimanCairo University, Cairo, Egypt.
Katharina KohlerNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1919-0193
Charlotte Jane WhiffinNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-9767-2123
Elijah KatamboNeurosurgery Department, University of Zambia University Teaching Hospital, Lusaka, Zambia.
Tommi K KorhonenNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.
Sami TetriDepartment of Neurosurgery, Neurocenter, Oulu University Hospital, Oulu, Finland.
Nourou Dine Adeniran BankoleCentre Hospitalier Régional Universitaire de Tours, Tours, France.ORCID http://orcid.org/0000-0002-4277-9767
Nicephorus RutabasibwaDepartment of Neurosurgery, Muhimbili Orthopaedic Institute, Dar es Salaam, Tanzania.
Arnold BhebheNeurosurgery Department, University of Zambia University Teaching Hospital, Lusaka, Zambia.
Thangaraj MunusamyNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.
Abenezer TirsitNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.
Kee B ParkProgram in Global Surgery and Social Change, Harvard Medical School Department of Global Health and Social Medicine, Boston, Massachusetts, USA.
Karol BudohoskiDepartment of Neurosurgery, University of Utah Health, Salt Lake City, Utah, USA.
Petra WahjoepramonoUniversitas Pelita Harapan, Tangerang, Indonesia.
Arina TamborskaDepartment of Epidemiology, Harvard T H Chan School of Public Health, Boston, Massachusetts, USA.
Deanna SaylorNeurosurgery Department, University of Zambia University Teaching Hospital, Lusaka, Zambia.
Tariq KhanNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.
Almas Fasih KhattakNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.
Anthony FigajiNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.
Angelos G KoliasNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-3992-0587
Tom BashfordNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-0228-9779
Alexis JoannidesNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.
Michael MartinObex Technologies, Cambridge, UK.
Rikin A TrivediNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.
Peter J HutchinsonNIHR Global Health Research Group on Acquired Brain and Spine Injury, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-2796-1835
PLOT-ICH Collaborative

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionStroke is the second leading cause of death worldwide, with the greatest burden in low- and middle-income countries (LMICs). Haemorrhagic stroke or spontaneous intracranial haemorrhage (sICH), including intraparenchymal haemorrhage (IPH) and subarachnoid haemorrhage (SAH), has the highest mortality and morbidity. Local management practices for haemorrhagic stroke vary greatly between geographical regions. The Planetary Outcomes after Intracranial Haemorrhage study aims to provide a global snapshot of the patient characteristics, processes of care and short-term outcomes of patients being treated for sICH across high- and low-income settings. It will also describe variation seen in care processes and available resources and time delays to receiving care. A greater understanding of the current state of sICH care is essential to identify possible interventions and targets for improved standards of care in all settings. METHODS AND ANALYSIS: We describe a planned prospective, multicentre, international observational cohort study of patients admitted to hospital for management of sICH. We will include patients of all ages presenting to hospital with imaging evidence of sICH (IPH, intraventricular haemorrhage and/or SAH). The study will collect patient, care process and short-term outcome data, following patients for up to 30 days (or until discharge or death, whichever occurs first). Any centre globally where patients with sICH are admitted and managed can participate, targeting a sample size of 712 patients. The study will recruit centres worldwide through pre-existing research networks and by dissemination through neurosurgical and stroke conferences and courses. Each participating centre will complete a site questionnaire alongside patient data collection. ETHICS AND DISSEMINATION: The study has received ethical approval by the University of Cambridge (PRE.2024.070). Participating centres will also confirm that they have undergone all necessary local governance procedures prior to starting local data collection. The findings will be disseminated via open access peer-reviewed journals, relevant conferences and other professional networks and lay channels, including the study website (https://plotich.org/) and social media channels (@plotichstudy). TRIALS REGISTRATION NUMBER: NCT06731751.

Indexed as

Intracranial HemorrhagesGlobal HealthHumansMulticenter Studies as TopicObservational Studies as TopicProspective StudiesResearch DesignBrain InjuriesIntracerebral HemorrhageStroke

Identifiers

PMID40897474
PMCPMC12406811

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.