Evidence map›Paper›PMID 40897471›Full record

ArticleLife science alliance2025

γδ T cells are the prime antitumoral T cells in pediatric neuroblastoma.

Suzanne M Castenmiller, Anne L Borst, Leyma Wardak, Jan J Molenaar, Maria Papadopoulou, Ronald R de Krijger, Alida Fw van der Steeg, Max M van Noesel, David Vermijlen, Rosa de Groot and 2 more

Abstract read
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Targeted therapies in pediatric oncology: A start.Molecular therapy. Oncology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Suzanne M CastenmillerSanquin Blood Supply Foundation, Department of Research, T Cell Differentiation Lab, Amsterdam, The Netherlands.ORCID 0000-0001-9751-980X
Anne L BorstPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Leyma WardakSanquin Blood Supply Foundation, Department of Research, T Cell Differentiation Lab, Amsterdam, The Netherlands.
Jan J MolenaarPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Maria PapadopoulouDepartment of Pharmacotherapy and Pharmaceutics, Université Libre de Bruxelles (ULB), Brussels, Belgium.ORCID 0000-0002-3006-1993
Ronald R de KrijgerPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Alida Fw van der SteegPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Max M van NoeselPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.ORCID 0000-0003-0503-5838
David VermijlenDepartment of Pharmacotherapy and Pharmaceutics, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Rosa de GrootSanquin Blood Supply Foundation, Department of Research, T Cell Differentiation Lab, Amsterdam, The Netherlands.ORCID 0000-0003-4070-0848
Judith WienkePrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.ORCID 0000-0002-3835-6374
Monika C WolkersSanquin Blood Supply Foundation, Department of Research, T Cell Differentiation Lab, Amsterdam, The Netherlands m.wolkers@sanquin.nl.ORCID 0000-0003-3242-1363

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-risk pediatric neuroblastoma patients have a dismal survival rate despite intensive treatment regimens. New treatment options are thus required. Even though HLA expression in neuroblastoma is low and immune cell infiltrates are limited, the presence of tumor-infiltrating lymphocytes (TILs) is indicative of better patient survival. Here, we show that most tumor lesions contain viable immune cell infiltrates after induction chemotherapy, with high percentages of CD3

Indexed as

Intraepithelial LymphocytesLymphocytes, Tumor-InfiltratingNeuroblastomaReceptors, Antigen, T-Cell, gamma-deltaT-LymphocytesCell Line, TumorChildChild, PreschoolFemaleHumansImmunotherapyImmunotherapy, AdoptiveInfantMaleReceptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID40897471
PMCPMC12405002

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.