Evidence map›Paper›PMID 40897225›Full record

ArticleEnvironmental research2025

Endocrine disrupting chemicals and female sexual health: An emerging research priority.

Julia Bond, Samantha Schildroth, Lauren A Wise

Abstract read
In one paragraph

Article in Environmental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Julia BondDepartment of Community Health Sciences, Boston University School of Public Health, Boston, MA, USA; Department of Epidemiology, Boston University School of Public Health, Boston MA, USA. Electronic address: jcbond@bu.edu.
Samantha SchildrothDepartment of Epidemiology, Boston University School of Public Health, Boston MA, USA. Electronic address: sschildr@bu.edu.
Lauren A WiseDepartment of Epidemiology, Boston University School of Public Health, Boston MA, USA.

Funding

An internet-based preconception cohort study in North America and DenmarkR01HD086742 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LAUREN A WISE · 2016 to 2026
$6.7M
A preconception cohort study of environmental chemicals, fertility, and miscarriageR01ES029951 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WISE, LAUREN A · 2019 to 2023
$3.1M
Female Sexual Dysfunction and Distress in the Preconception and Perinatal PeriodDP5OD039736 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Julia Craig Bond · 2025 to 2026
$818k
A Prospective Study of Per-and Polyfluoroalkyl Substance (PFAS) Mixtures and Pregnancy Outcomes among Black WomenK99ES036288 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Samantha Schildroth · 2025 to 2026
$242k
NICHD NIH HHS R01 HD086742NIEHS NIH HHS K99 ES036288NIEHS NIH HHS R01 ES029951NIH HHS DP5 OD039736
6 · The paper itself

Abstract

backgroundFemale sexual function is important for positive sexual expression, relationship satisfaction, and overall health and wellbeing. Female sexual dysfunction (FSD), which affects ∼40% of premenopausal women, may manifest as issues with sexual desire, arousal, orgasm, or pain during intercourse. The etiology of FSD is multifactorial but remains incompletely characterized, and endocrine disrupting chemicals (EDCs) may play an underappreciated role in its development.

objectiveIn this commentary, we identify female sexual function as a health outcome of interest for environmental health scientists by providing a high-level overview of the physiological systems underpinning sexual health, describing the hypothesized toxicological effects of EDCs on sexual function, and discussing research needs to advance science in this area. DISCUSSION: Female sexual function is understudied in environmental health research as an important and distinct health endpoint. Limited toxicological and epidemiological evidence suggests that EDCs may influence sexual health given their ability to dysregulate neurological and hormonal processes underlying female sexual function. Focusing future research efforts on EDCs and female sexual function will help to inform clinical practice, policies, and public health interventions with important implications for female sexuality, health, and wellbeing.

Indexed as

Endocrine DisruptorsEnvironmental PollutantsSexual Dysfunction, PhysiologicalSexual HealthWomen's HealthFemaleHumansEndocrine DisruptorsEnvironmental PollutantsEDCsReproductive healthSexual healthWomen

Identifiers

PMID40897225
PMCPMC12687382

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.