ReviewEpilepsy & behavior : E&B2025
Depression in older adults with epilepsy: Pathophysiology and management considerations.
Review in Epilepsy & behavior : E&B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Older adults with epilepsy are at an increased risk for comorbid depression, which worsens their quality of life. This review aims to outline the pathophysiological mechanisms thought to underly the comorbidity of depression in older adults with epilepsy and propose clinical and pharmacological considerations for the holistic management of depression in this population. Indeed, there is a wide range of reported prevalence of depression in older adults with epilepsy, yet these are likely underestimates since depression is underdiagnosed in this population. Age-related drivers of depression include biological and social risk factors such as neurodegenerative changes, inflammation, cerebrovascular dysfunction, social isolation, stigma, and poor health status. Additional contributors related to epilepsy include the impact of seizures, the effects of anti-seizure medications, and the role of sleep-disordered breathing. Therefore, the management of depression in older adults with epilepsy is centered on screening for depression and obstructive sleep apnea, careful choice of anti-seizure medications and anti-depressants, and the provision of social and psychological support.
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Registered trials
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