Astaxanthin Mitigates Dextran Sulfate Sodium-Induced Colitis in Mice by Repairing the Intestinal Barrier, Regulating Specific Intestinal Flora, and Reducing Inflammatory Cell Infiltration.

Guangzhe Shen, Du Yu, Longfei Xu, Tiezheng Yang

Abstract read

In one paragraph

Article in Journal of immunology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guangzhe ShenAnorectal Department, First Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun 130021, China.

Du YuAnorectal Department, First Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun 130021, China.

Longfei XuAnorectal Department, First Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun 130021, China.

Tiezheng YangAnorectal Department, First Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun 130021, China.ORCID https://orcid.org/0000-0002-0850-1702

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a dietary supplement for humans and animals, Astaxanthin (Ax) is widely believed to possess antioxidant and anti-inflammatory properties. In this study, we attempted to evaluate the protective effects of Ax on dextran sodium sulfate (DSS)-induced colitis in mice and the underlying molecular mechanism. Our results suggested that Ax significantly reduced the severity of DSS-induced colitis in mice, as evidenced by increased colon length, decreased disease activity index (DAI), and attenuated inflammatory factors. In addition, Ax significantly increased the diversity of gut microbiota in mice with colitis, remodeled the microbial composition, promoted the production of beneficial bacteria (e.g., Lactobacillaceae), and inhibited the production of harmful bacteria (e.g., Lachnospiraceae and Muribaculaceae). In conclusion, Ax alleviated DSS-induced colitis by maintaining the intestinal barrier and regulating intestinal microbes.

Indexed as

Anti-Inflammatory AgentsColitisGastrointestinal MicrobiomeIntestinal MucosaAnimalsColonDextran SulfateDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLXanthophyllsAnti-Inflammatory AgentsastaxanthineDextran SulfateXanthophyllsastaxanthin (Ax)colitisDSSintestinal barrierintestinal flora

Identifiers

PMID40896793

DOI10.1155/jimr/3381950

PMCPMC12393947

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.