Evidence map›Paper›PMID 40896791›Full record

ArticleNature physics2025

Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular ciliate

Shashank Shekhar, Hanliang Guo, Sean P Colin, Wallace Marshall, Eva Kanso, John H Costello

Abstract read
In one paragraph

Article in Nature physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Geometrical preference of anchoring sites in the unicellular organismProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Cooperative mixing through hydrodynamic interactions inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Shashank ShekharDepartments of Physics, Cell Biology and Biochemistry, Emory University, Atlanta, USA.
Hanliang GuoDepartment of Mathematics and Computer Science, Ohio Wesleyan University, Delaware, USA.
Sean P ColinWhitman Center, Marine Biological Laboratory, Woods Hole, USA.
Wallace MarshallDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, USA.
Eva KansoDepartment of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, USA.
John H CostelloWhitman Center, Marine Biological Laboratory, Woods Hole, USA.

Funding

Origins of Cell GeometryR35GM130327 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wallace Marshall · 2019 to 2026
$5.3M
MULTICOMPONENT MECHANOCHEMICAL REGULATION OF ACTIN FILAMENT END DYNAMICSR35GM143050 · NIGMS · EMORY UNIVERSITY · PI Shashank Shekhar · 2021 to 2026
$2.7M
Quantitative analysis of mucociliary clearance in airway ciliopathiesR01HL153622 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KANSO, EVA, RYAN, AMY LEANNE · 2021 to 2024
$1.9M
NHLBI NIH HHS R01 HL153622NIGMS NIH HHS R35 GM130327NIGMS NIH HHS R35 GM143050
6 · The paper itself

Abstract

Evolution of multicellularity from early unicellular ancestors is one of the most important transitions since the origin of life. Multicellularity is associated with enhanced nutrient uptake, better defense against predation, cell specialization and division of labor. While many single-celled organisms exhibit both solitary and colonial forms, the organizing principles governing the transition and the benefits endowed by the colonial states are less clear. Here, we use the suspension-feeding unicellular protist

Identifiers

PMID40896791
PMCPMC12392807

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.