Evidence map›Paper›PMID 40896713›Full record

ArticleAnnals of vascular medicine and research2024

Arterial Mechanics, Extracellular Matrix, and Smooth Muscle Differentiation in Carotid Arteries Deficient for Rac1.

Richard K Assoian, Tina Xu, Emilia Roberts

Abstract read
In one paragraph

Article in Annals of vascular medicine and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Richard K AssoianDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104.
Tina XuDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104.
Emilia RobertsDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia PA 19104.

Funding

ECM stiffness, mechanotransduction, and cell cyclingR01HL137232 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ASSOIAN, RICHARD · 2018 to 2021
$1.7M
NHLBI NIH HHS R01 HL137232
6 · The paper itself

Abstract

Stiffening of the extracellular matrix (ECM) occurs after vascular injury and contributes to the injury-associated proliferation of vascular smooth muscle cells (SMCs). ECM stiffness also activates Rac-GTP, and SMC Rac1 deletion strongly reduces the proliferative response to injury

Identifiers

PMID40896713
PMCPMC12393824

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.