ArticleIranian journal of basic medical sciences2025
Beyond chemotherapy: Exploring tree turmeric root and nano-hydroxyapatite for neuroprotective applications.
Article in Iranian journal of basic medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Breaking the Feedback Loop: A Model of Vicious Cycle for CIPN and Acupuncture-Medication Combination.Cancer management and research · 2026Review
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Authors and funding
3 authors.
Funding
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Abstract
Objectives: To investigate the physicochemical properties, in vitro efficacy, and in vivo therapeutic potential of novel tree turmeric root and nano-hydroxyapatite (TRE@NHA) composites in mitigating chemotherapy-induced peripheral neuropathy (CIPN). Materials and Methods: TRE@NHA composites were synthesized and characterized using FTIR, XRD, TGA, and HRTEM. In vitro studies using PC12 cells assessed cytotoxicity, anti-inflammatory effects, and neuroprotective properties. An in vivo rat model of CIPN was established using paclitaxel (PTX). Behavioral assessments, histopathological analysis, and oxidative stress markers were evaluated in sciatic nerve tissues. Results: TRE@NHA composites demonstrated successful integration of TRE into the NHA matrix. In vitro studies revealed significant anti-inflammatory and neuroprotective effects of TRE@NHA-2, particularly in suppressing cytokine production, enhancing cell viability, and mitigating oxidative stress. Conclusion: This study demonstrates the successful development and characterization of novel TRE@NHA composites. The findings strongly suggest that TRE@NHA-2 possesses promising therapeutic potential for mitigating CIPN due to its anti-inflammatory, antioxidant, and neuroprotective properties.
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