Evidence map›Paper›PMID 40896520›Full record

ArticleFrontiers in neural circuits2025

Volitional and forced running ability in mice lacking intact primary motor cortex.

Ryusei Abo, Mei Ishikawa, Rio Shinohara, Takayuki Michikawa, Itaru Imayoshi

Abstract read
In one paragraph

Article in Frontiers in neural circuits, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ryusei AboLaboratory of Brain Development and Regeneration, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Mei IshikawaLaboratory of Brain Development and Regeneration, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Rio ShinoharaLaboratory of Brain Development and Regeneration, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Takayuki MichikawaLaboratory of Optical Biomedical Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Itaru ImayoshiLaboratory of Brain Development and Regeneration, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coordination of various brain regions achieves both volitional and forced motor control, but the role of the primary motor cortex in proficient running motor control remains unclear. This study trained mice to run at high performance (>10,000 rotations per day or >2,700 rotations per hour) using a running wheel, and then assessed the effects of the removal of bilateral cortical areas including the primary motor cortex on volitional (self-initiated) and forced (externally driven) running locomotion. The control sham-operated group revealed a quick recovery of volitional running, reaching half of the maximum daily rotation in 3.9 ± 2.6 days (

Indexed as

Motor CortexRunningVolitionAnimalsMaleMiceMice, Inbred C57BLcerebrumcortical injurymotor controlrunning wheeltreadmill

Identifiers

PMID40896520
PMCPMC12391011

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.