Evidence map›Paper›PMID 40896500›Full record

ArticleAnimal nutrition (Zhongguo xu mu shou yi xue hui)2025

Branched-chain amino acids induce hyperammonemia via gut-liver axis-mediated ammonia overproduction in laying hens.

Huafeng Jian, Mengru Xu, Fang Liu, Libo Zhang, Qiuming Huang, Jiangang Ma, Xiaoting Zou, Xinyang Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal nutrition (Zhongguo xu mu shou yi xue hui), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huafeng JianZhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Key Laboratory for Animal Molecular Nutrition of Ministry of Education, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Mengru XuZhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Key Laboratory for Animal Molecular Nutrition of Ministry of Education, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Fang LiuZhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Key Laboratory for Animal Molecular Nutrition of Ministry of Education, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Libo ZhangZhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Key Laboratory for Animal Molecular Nutrition of Ministry of Education, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Qiuming HuangZhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Key Laboratory for Animal Molecular Nutrition of Ministry of Education, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Jiangang MaXianghu Laboratory, Hangzhou 311231, China.
Xiaoting ZouZhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Key Laboratory for Animal Molecular Nutrition of Ministry of Education, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Xinyang DongZhejiang Key Laboratory of Nutrition and Breeding for High-Quality Animal Products, Key Laboratory for Animal Molecular Nutrition of Ministry of Education, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota not only biosynthesizes branched-chain amino acids (BCAA) but also catabolizes and utilizes them, while the effects of dietary BCAA supplementation on intestinal microbiota and metabolism remain largely elusive. Therefore, the present study aimed to investigate the impacts of dietary BCAA supplementation on productive performance, egg quality, gut microbiota and metabolism in laying hens. A total of 180 Fengda No.1 laying hens aged 41 weeks were randomly assigned to five groups, with each group consisting of six replicates of six hens, and the experiment lasted for 8 weeks. The control group (Ctrl AA) was fed a basal diet, while the other four groups were supplemented with 67% leucine (High Leu), isoleucine (High Ile), both leucine and isoleucine (High Leu + Ile), or a combination of the three BCAA (High BCAA), respectively, based on the Ctrl AA. The results demonstrated that compared with Ctrl AA, both High Ile and High BCAA significantly decreased egg mass and laying rate (

Indexed as

AmmoniaBranched-chain amino acidGut microbiotaLaying henProductive performanceUrea metabolism

Identifiers

PMID40896500
PMCPMC12395079

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.