ArticleFrontiers in oncology2025
Analysis of survival differences in advanced triple-negative breast cancer: a real-world study.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Mechanotransduction-Induced Gene Expression Reveals Activation of TGFβ/SKIL/TAZ Axis and Supports Invasive Phenotype in Triple-Negative Breast Cancer.International journal of molecular sciences · 2026Article
- Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Advanced triple-negative breast cancer (aTNBC) has a poor prognosis, and there is a dearth of relevant real-world research data. This study is aimed at analyzing the survival outcomes and subgroup characteristics of aTNBC in the first-line treatment stage, providing data support for clinical treatment decisions. Methods: A retrospective analysis was conducted on 215 patients with aTNBC who received first-line salvage treatment at Shandong Cancer Hospital from January 2018 to March 2023 (74 patients of Results: The median PFS for aTNBC patients during the first-line treatment phase was 8.40 months (95% CI: 7.56-9.24 months), while the median OS was 23.87 months (95% CI: 20.53-27.21 months). Multivariate Cox regression and interaction analyses identified several independent prognostic factors affecting PFS, including dnMBC, platinum-containing regimen, immunotherapy, and local treatment of metastasis. For OS, independent prognostic factors included dnMBC, G3, and platinum-containing regimen. Additional survival analysis showed that the risk of disease progression and death was significantly lower in dnMBC patients compared to rMBC patients (PFS: HR = 0.70, 95% CI: 0.51-0.95, Conclusion: In patients with aTNBC, those with dnMBC demonstrate a more pronounced survival benefit, with this advantage being consistent across various clinicopathological parameters. Therefore, stratifying patients by metastatic category in clinical trials may improve evaluation of treatment efficacy and support more individualized patient management.
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