ArticleIntegrative medicine research2025
Effects of LIPOSA-T pharmacopuncture on localized fat as a fat dissolving injection via regulation of fat metabolism.
Article in Integrative medicine research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Excessive fat deposition in localized adiposity is known to induce severe medical diseases as well as aesthetic problems. Of late, LIPOSA-T pharmacopuncture, a new herbal pharmacopuncture consisting of the cortex of Methods: The network pharmacology analysis was carried out with the target gene sets of constituents of Results: The possible pathways and mechanism of action of LIPOSA-T were found to be mainly related to the fatty acid biosynthesis, glycolysis and glycogenesis in KEGG Pathways database. Subcutaneous injection of the LIPOSA-T pharmacopuncture significantly reduced the inguinal fat tissues weight and enlarged adipocyte size. In addition, the phosphorylated IRS with the PEPCK and G6p expressions were increased by the LIPOSA-T injection. Following the increase of AMPK expression, the fatty acid synthesis enzyme and lipolytic enzymes were regulated by the LIPOSA-T. Conclusions: Taken together, LIPOSA-T exerted the catabolic effects on fat deposition in obesity by regulating the glucose production, lipid synthesis and TAG hydrolysis in consistent with the prediction results. Based on the findings, LIPOSA-T pharmacopuncture is expected to be a dissolving injection for localized fat.
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