ReviewFrontiers in neuroscience2025
Role of the YWHAG gene mutations in Developmental and Epileptic Encephalopathy.
Review in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed.
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Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
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Abstract
Developmental and Epileptic Encephalopathy (DEE) is a severe neurological condition characterized by epileptic seizures and cognitive developmental impairments. Mutations in the YWHAG gene, which encodes the 14-3-3γ protein, are implicated in DEE. Predominantly expressed in the brain, 14-3-3γ regulates various cellular processes, forming homodimers or heterodimers with other isoforms. It binds to phosphorylated sites on target proteins, influencing their activity, stability, or cellular localization. This review evaluates the association between YWHAG mutations and DEE, the mechanisms by which 14-3-3γ influences neuronal function, and potential therapeutic interventions. YWHAG mutations, often
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