Evidence map›Paper›PMID 40896276›Full record

ReviewAging medicine (Milton (N.S.W))2025

Tendon Aging: A Silent Enemy Revealed Strategies for Effective Treatment.

Wenhui Gu, Guohua Wang, Haifeng Zhang, Yinxian Yu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Aging medicine (Milton (N.S.W)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Role of Phagocytic Cells in the Achilles Tendon.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wenhui GuDepartment of Physiology and Hypoxic Biomedicine, Institute of Special Environmental Medicine Nantong University Nantong China.ORCID https://orcid.org/0009-0006-2298-5287
Guohua WangDepartment of Physiology and Hypoxic Biomedicine, Institute of Special Environmental Medicine Nantong University Nantong China.
Haifeng ZhangDepartment of Orthopaedic Surgery, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Yinxian YuDepartment of Orthopaedic Surgery, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tendons have a special makeup and set of physiological characteristics that make it difficult for them to mend themselves after damage. Aged tendons are more prone to injury, and wounded tendons will also age faster than usual. This creates a vicious cycle that might cause an injured tendon to reach surgery standards earlier than necessary or cause a re-injury after surgery. Nowadays, the utilization of appropriate medications and exercise is the mainstay of tendon aging treatment. Due to their high potential for differentiation, tendon stem/progenitor cells (TSPCs) have drawn the attention of an increasing number of studies. The mechanism of tendon aging is outlined in this review, along with how it is caused by oxidative stress, hyperglycemia, inflammation, cell apoptosis, fatty infiltration, and its relationship to TSPCs. The goal of this review was to investigate the mechanism of aging and identify related treatment strategies that can effectively prevent further deterioration, slow down tendon aging, and minimize the risk of tendon re-injury following surgery.

Indexed as

tendonTendon agingTendon Stem/Progenitor Cells

Identifiers

PMID40896276
PMCPMC12399342

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.