Evidence map›Paper›PMID 40896243›Full record

ArticleEJHaem2025

Adipocytes Impair Mitoxantrone Cytotoxicity Against Acute Lymphoblastic Leukemia.

Michael Cohen, Etan Orgel, Jessica Nevarez-Mejia, Ting Chen, Michael Neely, Stan Louie, Steven D Mittelman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJHaem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael CohenDivision of Pediatric Endocrinology UCLA Children's Discovery and Innovation Institute David Geffen School of Medicine University of California Los Angeles Los Angeles California USA.
Etan OrgelCancer and Blood Disease Institute Children's Hospital Los Angeles Los Angeles California USA.
Jessica Nevarez-MejiaDivision of Pediatric Endocrinology UCLA Children's Discovery and Innovation Institute David Geffen School of Medicine University of California Los Angeles Los Angeles California USA.
Ting ChenDivision of Pediatric Endocrinology UCLA Children's Discovery and Innovation Institute David Geffen School of Medicine University of California Los Angeles Los Angeles California USA.
Michael NeelyDepartment of Pediatrics Keck School of Medicine University of Southern California Los Angeles California USA.
Stan LouieMann School of Pharmacy and Pharmaceutical Sciences Keck School of Medicine University of Southern California Los Angeles California USA.
Steven D MittelmanDivision of Pediatric Endocrinology UCLA Children's Discovery and Innovation Institute David Geffen School of Medicine University of California Los Angeles Los Angeles California USA.ORCID https://orcid.org/0000-0003-2867-1298

Funding

Sequestration and deactivation of anthracycline by adipocytes in the leukemia microenvironmentR01CA213129 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LOUIE, STAN GEE, MITTELMAN, STEVEN DAVID · 2017 to 2021
$1.9M
NCI NIH HHS R01 CA213129
6 · The paper itself

Abstract

Introduction: Obesity contributes to poorer clinical outcomes in patients with acute lymphoblastic leukemia. We have shown that adipocytes cause anthracycline resistance by absorbing and metabolizing them into less-active alcohol metabolites. Methods: We hypothesized that mitoxantrone, which has a similar cytotoxic mechanism to anthracyclines but is metabolized through different pathways, might overcome this adipocyte-mediated chemoresistance. We treated human BV173 acute lymphoblastic leukemia cells with daunorubicin and mitoxantrone that had been incubated with or without 3T3-L1 adipocytes. Results: Contrary to our hypothesis, adipocytes induced similar chemoresistance to both drugs. Conclusion: Mitoxantrone is unlikely to be an attractive alternative to overcome adipocyte-mediated anthracycline resistance in patients with obesity. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.

Indexed as

acute leukemiachemotherapydrug resistancepharmacokinetics

Identifiers

PMID40896243
PMCPMC12397950

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.