ArticleRegenerative therapy2025
Resolve D1 promotions the repair of cornal epidemiological damage in diabetes by regulating epidemiological response and oxidative stress.
Article in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Comparative Anatomical and Morphometric Analysis of Eustachian Tube Across Species.Audiology research · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: It aimed to thoroughly analyze the promotive outcome of Resolvin D1 (RvD1) on the repair of corneal epithelium (CE) damage in diabetes mellitus (DM) mice and its molecular mechanisms. Methods: 27 male C57BL/6J mice were selected. Type 1 diabetes mellitus(T1DM) mice models were prepared by streptozotocin (STZ) intraperitoneal injection (IPI), and central CE scraping was performed on all mice. They were grouped: Group S1 (S1G, RvD1 treatment), Group S2 (S2G, DM mice), and Group D0 (D0G, normal mice). The CE defect area and sensitivity, the expression of CE regeneration pathway-related factors and oxidative stress (OS) indicators, and the expression of antioxidant genes, inflammatory-related factors were compared. Results: As against S2G, in D0G and S1G, the corneal defect area was visibly smaller at 1, 2, and 3 d post-surgery, and the corneal sensitivity was consistently greater from 1 to 9 d; The content of Conclusion: RvD1 has been shown to effectively improve corneal repair capabilities in DM mice, alleviate corneal damage, and enhance corneal sensitivity. Its effects may be mediated by regulating factors related to corneal epithelial regeneration, thereby promoting the repair and regeneration of the CE. Additionally, it mitigates OS responses induced by DM, reduces free radical damage, and further facilitates corneal healing.
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