ArticleRegenerative therapy2025
Extracellular vesicles-delivered circDB promotes ischemic muscle repair through the miR-34a/USP7/Notch1 signaling pathway.
Article in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The incidence of lower limb ischemic diseases has been rising steadily in recent years, often leading to severe outcomes such as limb amputation. Given the limited availability of effective treatments, there is a critical need for novel therapeutic strategies. This study explores the reparative role and underlying mechanisms of extracellular vesicles derived from human umbilical cord mesenchymal stem cells (UMSC-EVs) in promoting ischemic hindlimb recovery through the delivery of circular RNA circDB. Methods: A hindlimb ischemia model was established in C57BL/6 mice Results: We found that circDB expression is markedly reduced in ischemic hindlimb tissues and is closely associated with tissue repair. In a murine hindlimb ischemia model, localized injection of UMSC-EVs into ischemic muscle significantly enhanced blood flow recovery, improved muscle function, and increased expression of USP7 and Notch1. Additionally, a hypoxia-induced myoblast injury model Conclusion: Extracellular vesicles circDB enhances ischemic muscle repair by modulating the miR-34a/USP7/Notch1 pathway. These findings highlight a novel mechanism by which UMSC-derived extracellular vesicles facilitate muscle regeneration and suggest a promising therapeutic approach for lower limb ischemic diseases.
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