ArticleTobacco induced diseases2025
Lifestyle-attributable burden of young-onset stroke in Chinese and global populations aged 20-54 years: A three decades comparative study (1990-2021) using Global Burden of Disease study data.
Article in Tobacco induced diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionYoung-onset stroke represents a growing public health crisis globally along with rapid lifestyle changes. This study investigated the mortality and disability burden of young-onset stroke attributable to modifiable lifestyle factors in China compared with global trends, aiming to identify critical intervention targets.
methodsUtilizing Global Burden of Disease 1990-2021 data, we analyzed age-stratified mortality and disability-adjusted life years for four lifestyle risk factors (tobacco, high alcohol use, dietary risk, and low physical activity). Temporal trends were assessed through joinpoint regression and age-period-cohort modeling, with population-attributable fractions compared between Chinese and global populations over three decades.
resultsChina demonstrated persistently greater burdens from tobacco and high alcohol use than global averages did, particularly among males, where alcohol-attributable disability-adjusted life years (DALYs) increased 21% faster than mortality rates did. Gender disparities were prominent, with male population attributable fractions (PAFs) for alcohol exceeding female levels by 9.3-fold. Paradoxically, Chinese females presented rising low physical activity-related DALYs despite declining mortality. Midlife adults (aged ≥40 years) showed accelerated risk accumulation, whereas dietary risk reductions in China outpaced global declines by 2.4-fold. Age effects for all risks were weaker than global estimates, although period and cohort patterns aligned closely.
conclusionsThe diverging trajectories of mortality and disability burdens underscore China's dual challenge: curbing substance-related mortality in young males while containing midlife disability escalation. Culturally tailored strategies addressing gender-specific risk profiles and alcohol-DALY decoupling are urgently needed. These findings provide pivotal evidence for global stroke prevention in transitioning societies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.