Evidence map›Paper›PMID 40896115›Full record

ArticleRSC chemical biology2025

Differential melting voltage by tandem-trapped ion mobility spectrometry: glycan structure influences glycoprotein stability.

Mengqi Chai, Christian Bleiholder, Fanny C Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mengqi ChaiDepartment of Chemistry and Biochemistry, Florida State University, 102 Varsity Way Tallahassee Florida 32306 USA fliu@fsu.edu.ORCID https://orcid.org/0000-0002-6363-0216
Christian BleiholderDepartment of Chemistry and Biochemistry, Florida State University, 102 Varsity Way Tallahassee Florida 32306 USA fliu@fsu.edu.ORCID https://orcid.org/0000-0002-4211-1388
Fanny C LiuDepartment of Chemistry and Biochemistry, Florida State University, 102 Varsity Way Tallahassee Florida 32306 USA fliu@fsu.edu.ORCID https://orcid.org/0000-0003-1403-7114

Funding

Elucidating the structural heterogeneity of differentially modified protein systems by tandem-ion mobility spectrometry / mass spectrometry methods.R01GM135682 · NIGMS · FLORIDA STATE UNIVERSITY · PI BLEIHOLDER, CHRISTIAN · 2019 to 2022
$1.3M
NIGMS NIH HHS R01 GM135682
6 · The paper itself

Abstract

Profiling the full spectrum of protein glycoforms is critical to understanding their functional roles. We developed the differential melting voltage approach using tandem-ion mobility/tandem-mass spectrometry and applied it to study Ribonuclease B glycoforms. Our results indicate that, in addition to glycan mass and intact protein size, the glycan structure plays a role in regulating the stability of Ribonuclease B.

Identifiers

PMID40896115
PMCPMC12394896

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.