Evidence map›Paper›PMID 40896071›Full record

ArticleCureus2025

Late Administration of Remdesivir, Guided by Antigen Test Results, in a Patient Experiencing Difficulty Weaning From the Ventilator Due to Severe COVID-19 Pneumonia.

Keisuke Mataichi, Takuo Yoshida

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Keisuke MataichiDivision of Intensive Care, Department of Emergency and Disaster Medicine, Kashiwa Hospital, The Jikei University School of Medicine, Tokyo, JPN.
Takuo YoshidaDivision of Intensive Care, Department of Emergency and Disaster Medicine, Kashiwa Hospital, The Jikei University School of Medicine, Tokyo, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 70-year-old woman with a history of malignant lymphoma (in remission) and systemic sclerosis required mechanical ventilation because of severe coronavirus disease 2019 pneumonia. Despite the administration of broad-spectrum antibiotics, antifungal agents, and corticosteroids, respiratory failure persisted, and a tracheostomy was performed on hospital day 17. Ventilator weaning remained difficult up to hospital day 30 and persistent detection of the severe acute respiratory syndrome coronavirus 2 antigen prompted initiation of remdesivir. Treatment was continued until the antigen became undetectable, after which successful ventilator weaning was achieved. This case suggests an association between prolonged antigen presence and sustained respiratory failure.

Indexed as

antigen testingantiviral therapymechanical ventilationremdesivirrespiratory failuresevere covid-19 pneumonia

Identifiers

PMID40896071
PMCPMC12398666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.