Evidence map›Paper›PMID 40896062›Full record

ArticleCureus2025

A Case of Amyloid Beta-Related Angiitis: Rare Inflammatory Vasculopathy of the Central Nervous System.

Sai Varun Bethina, Asish Gulati, Tamra I Ranasinghe

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sai Varun BethinaDepartment of Neurology, Virginia Commonwealth University School of Medicine, Richmond, USA.
Asish GulatiDepartment of Neurology and Rehabilitation Medicine, George Washington University Hospital, Washington, DC, USA.
Tamra I RanasingheDepartment of Neurology, Mayo Clinic, Phoenix, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral amyloid angiopathy (CAA) is associated with amyloid-beta deposition in cerebrovascular vessels, leading to spontaneous intracerebral hemorrhage (ICH). A rare manifestation, amyloid beta-related angiitis (ABRA), presents with symptoms including subacute progressive headaches, cognitive decline, and focal neurological deficits. This case report discusses a 78-year-old female patient with a history of hypertension who exhibited symptoms consistent with ABRA, including headaches and memory impairments. Diagnostic imaging revealed significant MRI findings of confluent hyperintensities and microhemorrhages, while a temporal brain biopsy confirmed granulomatous arteritis linked to amyloid angiopathy. Treatment with corticosteroids resulted in notable clinical improvement. This report underscores the importance of early diagnosis and intervention in ABRA, promoting the establishment of non-invasive diagnostic criteria to distinguish it from other CAA-related conditions, thereby potentially facilitating prompt treatment without the necessity for invasive procedures.

Indexed as

abracerebral amyloid angiopathy (caa)cerebral amyloid angiopathy-related inflammationcerebral vasculopathyprimary angiitis of the central nervous system (pacns)

Identifiers

PMID40896062
PMCPMC12393810

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.