ReviewCureus2025
Efficacy of Mineral Trioxide Aggregate Versus Biodentine as a Direct Pulp Capping Material in Carious Human Mature Permanent Teeth: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Regenerative endodontic treatment for premolars with apical root segment separation and extensive periapical lesions secondary to severe inflammatory root resorption: A report of two cases.Experimental and therapeutic medicine · 2026Article
- Clinical and radiographic outcomes of partial pulpotomy procedure in primary molars utilising different capping materials and different sealing methods: a randomised clinical trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Modern Drug Delivery Platforms Based on Photocrosslinkable Hydrogels (PCHs) in Dentistry: From Material Characteristics to Clinical Applications-A Review.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Endodontic treatment of a molar-incisor malformation of the maxillary first molar: a case report.Restorative dentistry & endodontics · 2026Article
- Clinical and Radiographic Outcomes of Vital Pulp Therapy Using Resin-Modified Versus Conventional Calcium Silicate-Based Materials: A Systematic Review and Meta-Analysis.Journal of functional biomaterials · 2026Review
- Decision-ready evidence for vital pulp therapy: a network meta-analysis of bioactive materials in mature permanent teeth.Frontiers in dental medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present systematic review and meta-analysis aimed to evaluate and compare the clinical efficacy of Mineral Trioxide Aggregate (MTA) and Biodentine (BD) as direct pulp capping materials in cariously exposed mature permanent teeth, focusing on outcomes such as pulp vitality preservation, dentin bridge formation, and complication rates, including tooth discoloration. A comprehensive literature search was conducted across PubMed, Scopus, Web of Science, and other dental databases following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The review protocol was registered in PROSPERO (CRD42023463513). Eligible studies included randomized controlled trials and retrospective studies reporting clinical and radiographic success. Risk of bias was assessed using the Cochrane Risk of Bias Tool and the Newcastle-Ottawa Scale. Eleven studies involving 373 treated teeth were included. Meta-analysis revealed a pooled risk ratio (RR) for success of 0.98 (95% CI: 0.94-1.03), slightly favoring MTA but without statistical significance. BD showed a lower failure rate (RR = 1.94; 95% CI: 0.48-7.94) and marginally better outcomes in calcific bridge formation (RR = 0.90; 95% CI: 0.75-1.08), though these differences were also not statistically significant. Biodentine demonstrated superior handling, a shorter setting time (about 12 minutes), and no risk of discoloration, which is an issue noted with MTA. Both materials are clinically effective, but BD may be preferable due to its practical and aesthetic advantages. Further long-term, standardized studies are recommended.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.