ArticleCureus2025
Association Between Nerve Block Injection and Short-Term Outcomes in Patients With Acute Low Back Pain: Findings From the Acute Low Back Pain Study, a Prospective Observational Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Background Acute low back pain is a leading cause of disability worldwide. While clinical guidelines offer general management strategies, real-world evidence on nerve block therapy for acute low back pain in primary care remains limited. Methods We conducted a prospective, multicenter observational cohort study at 19 private pain clinics in Japan from June 2021 to March 2022. Patients with acute low back pain onset within the past seven days were enrolled and followed for seven days. Clinical decisions, including nerve block administration, were made at the physician's discretion. Patient-reported outcomes were collected via web- or paper-based questionnaires and compared between patients who received nerve block injections and those who did not. The primary outcome was the change in Pain Disability Assessment Scale (PDAS) scores from baseline to Day 3; secondary outcomes included PDAS changes on Day 7 and Visual Analog Scale (VAS) scores for seven consecutive days. Multivariable regression models were used to adjust for confounding factors. Results A total of 567 patients were analyzed (523 injected; 44 non-injected). Among patients with baseline PDAS scores ≥ 45, those who received injections showed significantly greater improvement on Day 3. The mean differences (95％ confidence interval (CI) ) in PDAS scores were -6.42 (-12.48 to -0.36) (
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