Evidence map›Paper›PMID 40895874›Full record

ArticleCureus2025

Association Between Iron Deficiency Without Anemia and Cognitive Impairment in Children.

Alka Kumari, Lawson O Obazenu, Manahil Monis, Halimah T Mustapha-Adebiyi, Abali Wandala, Thithiksha Venkata Harischandra, Person Domshak Ayuba, Mahek Thorani, Muhammad Rahim Arshad, Meera Al Shamsi and 1 more

Abstract read
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alka KumariMedicine, Liaquat University of Medical and Health Sciences, Hyderabad, PAK.
Lawson O ObazenuMedicine, University of Ibadan, Ibadan, NGA.
Manahil MonisInternal Medicine, Neurowave Research Center, Islamabad, PAK.
Halimah T Mustapha-AdebiyiInternal Medicine, Lagos State University College of Medicine, Lagos, NGA.
Abali WandalaFCS-Medicine, Universidad Adventista del Plata, Libertador San Martín, ARG.
Thithiksha Venkata HarischandraInternal Medicine, Stanley Medical College, Chennai, IND.
Person Domshak AyubaFamily Medicine, University of Jos, Jos, NGA.
Mahek ThoraniInternal Medicine, People's University of Medical and Health Sciences for Women, Karachi, PAK.
Muhammad Rahim ArshadInternal Medicine, Adam University, Bishkek, KGZ.
Meera Al ShamsiGenetics, Zayed Higher Organization for People of Determination, Abu Dhabi, ARE.
Alzahrani Renad Mohammed AInternal Medicine, Al Baha University, Al Baha, SAU.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIron deficiency without anemia is a potentially serious, under-recognized nutritional problem that may adversely influence children's cognitive and behavioral development. Although the connection is supported globally, there is a lack of localized studies in Pakistan. This research investigates the relationship between iron deficiency without anemia and cognitive-behavioral problems in Pakistani children aged 5-18. METHODOLOGY: This cross-sectional study was conducted from February to June 2025, using convenience sampling of schools and communities in Islamabad. A total of 385 children participated. A three-part structured questionnaire, an Iron Deficiency Risk Questionnaire (IDRQ), and the Strengths and Difficulties Questionnaire (SDQ) were used to gather demographic data. Statistical analyses were performed using SPSS Version 26 (IBM Corp., Armonk, NY). They consisted of descriptive statistics, t-tests, analysis of variance (ANOVA), Pearson correlation, and linear regression to evaluate associations between the risk of iron deficiency and cognitive-behavioral functioning.

resultsThe sample consisted of 385 participants (

conclusionsThe results indicate that iron deficiency without anemia is weakly associated with cognitive and behavioral issues among children. Although the correlation is statistically significant, it is modest, indicating the need for further research to fully understand the extent of this relationship. Community-based nutritional interventions are critical in reducing this hidden burden by recognizing that early detection enables better developmental outcomes among Pakistani children.

Indexed as

behavioral problemschildrencognitive functioniron deficiencynonanemic iron deficiency

Identifiers

PMID40895874
PMCPMC12395840

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.